Cross-modal plasticity in cortical development: differentiation and specification of sensory neocortex

Mriganka Sur, Sarah L. Pallas, Anna W. Roe

Research output: Contribution to journalReview article

128 Scopus citations


Early developmental manipulations can induce sensory afferents of one modality to project to central targets of a different sensory modality. We and other investigators have used such cross-modal plasticity to examine the role of afferent inputs and their patterns of activity in the development of sensory neocortex. We suggest that the afferent rewiring can significantly influence the internal connectivity or microcircuitry of sensory cortex, aspects of which appear to be determined or specified relatively late in development, but that they cannot influence, or influence only to a minor extent, the laminar characteristics and external connectivity patterns of cortex, which appear to be specified earlier.

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalTrends in Neurosciences
Issue number6
StatePublished - Jun 1990


ASJC Scopus subject areas

  • Neuroscience(all)

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