TY - JOUR
T1 - Cross-modal plasticity in cortical development
T2 - differentiation and specification of sensory neocortex
AU - Sur, Mriganka
AU - Pallas, Sarah L.
AU - Roe, Anna W.
N1 - Funding Information:
We thank Peter HeLl and HenningS cheich for access to unpublishedd ata, SonalJ haveri, Gerald Schneidera nd Pat// Katz for their comments on the manuscript, and TeresaS ullivan for assistance with the figures. Our work has been supportedb y grants from the NIH and the McKniEht Foundation.
PY - 1990/6
Y1 - 1990/6
N2 - Early developmental manipulations can induce sensory afferents of one modality to project to central targets of a different sensory modality. We and other investigators have used such cross-modal plasticity to examine the role of afferent inputs and their patterns of activity in the development of sensory neocortex. We suggest that the afferent rewiring can significantly influence the internal connectivity or microcircuitry of sensory cortex, aspects of which appear to be determined or specified relatively late in development, but that they cannot influence, or influence only to a minor extent, the laminar characteristics and external connectivity patterns of cortex, which appear to be specified earlier.
AB - Early developmental manipulations can induce sensory afferents of one modality to project to central targets of a different sensory modality. We and other investigators have used such cross-modal plasticity to examine the role of afferent inputs and their patterns of activity in the development of sensory neocortex. We suggest that the afferent rewiring can significantly influence the internal connectivity or microcircuitry of sensory cortex, aspects of which appear to be determined or specified relatively late in development, but that they cannot influence, or influence only to a minor extent, the laminar characteristics and external connectivity patterns of cortex, which appear to be specified earlier.
UR - http://www.scopus.com/inward/record.url?scp=0025291726&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025291726&partnerID=8YFLogxK
U2 - 10.1016/0166-2236(90)90165-7
DO - 10.1016/0166-2236(90)90165-7
M3 - Review article
C2 - 1694329
AN - SCOPUS:0025291726
SN - 0166-2236
VL - 13
SP - 227
EP - 233
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 6
ER -