Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients

A. M. Api, D. Belsito, M. Bruze, P. Cadby, P. Calow, M. L. Dagli, W. Dekant, G. Ellis, Allison Fryer, M. Fukayama, P. Griem, C. Hickey, L. Kromidas, J. F. Lalko, D. C. Liebler, Y. Miyachi, V. T. Politano, K. Renskers, G. Ritacco, D. SalvitoT. W. Schultz, I. G. Sipes, B. Smith, D. Vitale, D. K. Wilcox

Research output: Contribution to journalArticle

465 Citations (Scopus)

Abstract

The Research Institute for Fragrance Materials, Inc. (RIFM) has been engaged in the generation and evaluation of safety data for fragrance materials since its inception over 45 years ago. Over time, RIFM's approach to gathering data, estimating exposure and assessing safety has evolved as the tools for risk assessment evolved. This publication is designed to update the RIFM safety assessment process, which follows a series of decision trees, reflecting advances in approaches in risk assessment and new and classical toxicological methodologies employed by RIFM over the past ten years. These changes include incorporating 1) new scientific information including a framework for choosing structural analogs, 2) consideration of the Threshold of Toxicological Concern (TTC), 3) the Quantitative Risk Assessment (QRA) for dermal sensitization, 4) the respiratory route of exposure, 5) aggregate exposure assessment methodology, 6) the latest methodology and approaches to risk assessments, 7) the latest alternatives to animal testing methodology and 8) environmental risk assessment. The assessment begins with a thorough analysis of existing data followed by in silico analysis, identification of 'read across' analogs, generation of additional data through in vitro testing as well as consideration of the TTC approach. If necessary, risk management may be considered.

Original languageEnglish (US)
Pages (from-to)S1-S19
JournalFood and Chemical Toxicology
Volume82
Issue numberS
DOIs
StatePublished - Aug 1 2015

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Fragrances
Risk assessment
ingredients
odors
Safety
Toxicology
aggregate exposure
risk assessment
animal use alternatives
risk assessment process
Animal Testing Alternatives
quantitative risk assessment
exposure pathways
exposure assessment
safety assessment
environmental assessment
risk management
methodology
Decision Trees
Process Assessment (Health Care)

Keywords

  • Environmental toxicology
  • Fragrance material
  • Human health toxicology
  • Safety assessment

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients. / Api, A. M.; Belsito, D.; Bruze, M.; Cadby, P.; Calow, P.; Dagli, M. L.; Dekant, W.; Ellis, G.; Fryer, Allison; Fukayama, M.; Griem, P.; Hickey, C.; Kromidas, L.; Lalko, J. F.; Liebler, D. C.; Miyachi, Y.; Politano, V. T.; Renskers, K.; Ritacco, G.; Salvito, D.; Schultz, T. W.; Sipes, I. G.; Smith, B.; Vitale, D.; Wilcox, D. K.

In: Food and Chemical Toxicology, Vol. 82, No. S, 01.08.2015, p. S1-S19.

Research output: Contribution to journalArticle

Api, AM, Belsito, D, Bruze, M, Cadby, P, Calow, P, Dagli, ML, Dekant, W, Ellis, G, Fryer, A, Fukayama, M, Griem, P, Hickey, C, Kromidas, L, Lalko, JF, Liebler, DC, Miyachi, Y, Politano, VT, Renskers, K, Ritacco, G, Salvito, D, Schultz, TW, Sipes, IG, Smith, B, Vitale, D & Wilcox, DK 2015, 'Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients', Food and Chemical Toxicology, vol. 82, no. S, pp. S1-S19. https://doi.org/10.1016/j.fct.2014.11.014
Api, A. M. ; Belsito, D. ; Bruze, M. ; Cadby, P. ; Calow, P. ; Dagli, M. L. ; Dekant, W. ; Ellis, G. ; Fryer, Allison ; Fukayama, M. ; Griem, P. ; Hickey, C. ; Kromidas, L. ; Lalko, J. F. ; Liebler, D. C. ; Miyachi, Y. ; Politano, V. T. ; Renskers, K. ; Ritacco, G. ; Salvito, D. ; Schultz, T. W. ; Sipes, I. G. ; Smith, B. ; Vitale, D. ; Wilcox, D. K. / Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients. In: Food and Chemical Toxicology. 2015 ; Vol. 82, No. S. pp. S1-S19.
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