CRF enhancement of GIRK channel-mediated transmission in dopamine neurons

Michael J. Beckstead, Stephanie C. Gantz, Christopher P. Ford, Mary Stenzel-Poore, Paul E M Phillips, Gregory Mark, John Williams

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Dopamine neurons in the ventral midbrain contribute to learning and memory of natural and drug-related rewards. Corticotropin-releasing factor (CRF), a stress-related peptide, is thought to be involved in aspects of relapse following drug withdrawal, but the cellular actions are poorly understood. This study investigates the action of CRF on G-protein-linked inhibitory postsynaptic currents (IPSCs) mediated by GIRK (Kir3) channels in dopamine neurons. CRF enhanced the amplitude and slowed the kinetics of IPSCs following activation of D2-dopamine and GABA B receptors. This action was postsynaptic and dependent on the CRF 1 receptor. The enhancement induced by CRF was attenuated by repeated in vivo exposures to psychostimulants or restraint stress. The results indicate that CRF influences dopamine- and GABA-mediated inhibition in the midbrain, suggesting implications for the chronic actions of psychostimulants and stress on dopamine-mediated behaviors.

Original languageEnglish (US)
Pages (from-to)1926-1935
Number of pages10
JournalNeuropsychopharmacology
Volume34
Issue number8
DOIs
StatePublished - Jul 2009

Fingerprint

Dopaminergic Neurons
Corticotropin-Releasing Hormone
Dopamine
Inhibitory Postsynaptic Potentials
Mesencephalon
GABA-B Receptors
Reward
GTP-Binding Proteins
Pharmaceutical Preparations
gamma-Aminobutyric Acid
Learning
Recurrence
Peptides

Keywords

  • D2
  • GABAB
  • IPSC
  • Methamphetamine
  • Mouse
  • Stress

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

CRF enhancement of GIRK channel-mediated transmission in dopamine neurons. / Beckstead, Michael J.; Gantz, Stephanie C.; Ford, Christopher P.; Stenzel-Poore, Mary; Phillips, Paul E M; Mark, Gregory; Williams, John.

In: Neuropsychopharmacology, Vol. 34, No. 8, 07.2009, p. 1926-1935.

Research output: Contribution to journalArticle

Beckstead, Michael J. ; Gantz, Stephanie C. ; Ford, Christopher P. ; Stenzel-Poore, Mary ; Phillips, Paul E M ; Mark, Gregory ; Williams, John. / CRF enhancement of GIRK channel-mediated transmission in dopamine neurons. In: Neuropsychopharmacology. 2009 ; Vol. 34, No. 8. pp. 1926-1935.
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