Creutzfeldt-Jakob disease as a cause of dementia

Rasha Nakhleh, Sophia Tenaye Tessema, Abdullahi Mahgoub

Research output: Contribution to journalArticlepeer-review


Creutzfeldt-Jakob disease (CJD) is a rapidly progressive, fatal neurodegenerative disorder belonging to the family of transmissible spongiform encephalopathies. The disease is believed to be caused by an abnormal isoform of a cellular glycoprotein known as the prion protein. Our patient is an 84-year-old Caucasian man who presented to the geriatric clinic for evaluation of short-term memory loss and decreased concentration which started 3 months prior to initial evaluation. Rapid progression of dementia demonstrated by severe impairment in tasks with a predominantly visual component, including visual scanning, perceptual reasoning and visual spatial processing. Diagnosis of CJD was determined by characteristic ribboning on brain MRI as well as notable real-time quaking-induced conversion on cerebrospinal fluid.

Original languageEnglish (US)
Article numbere240020
JournalBMJ Case Reports
Issue number5
StatePublished - May 11 2021


  • general practice / family medicine
  • memory disorders
  • neuroimaging

ASJC Scopus subject areas

  • Medicine(all)


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