CREB signaling--timing is everything.

S. Impey, R. H. Goodman

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Depolarization of neurons can lead to changes in gene expression that are important for such processes as synaptic plasticity, neuronal differentiation, and apoptosis. Impey and Goodman discuss some of the opposing models for how gene transcription in response to neuronal activity and elevations in intracellular calcium concentration is regulated. The pathways appear to converge on cyclic AMP response element-binding (CREB) protein, with the mitogen-activated protein kinase pathways playing an important role. The continuing debate about the involvement of calmodulin kinase IV is also described.

Original languageEnglish (US)
Pages (from-to)PE1
JournalScience's STKE : signal transduction knowledge environment
Issue number82
StatePublished - May 15 2001

ASJC Scopus subject areas

  • Medicine(all)


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