Craniofacial manifestations of β-thalassemia major

Bahram Javid, Nasser Said-Al-Naief

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hemoglobinopathies are by far the most common genetic diseases, affecting millions worldwide with a prevalence for natives of Iran, Southeast Asia, and the Caspian Sea, as part of the so-called Thalassemia Belt, and an overall incidence ranging approximately from 3 to 100 patients per 100,000 population. β-Thalassemia major is of particular significance, providing bad outcomes despite aggressive therapeutic approaches. We report a case of β-thalassemia in a 5-year-old Persian boy who presented with classical diagnostic features of the disease and who did not survive despite an aggressive management approach. A review of the clinical, radiographic, laboratory, and therapeutic characteristics as well as diagnostic tests of this disease is also presented. The multifactorial challenges that face clinicians in the management of this serious disease are also reviewed.

Original languageEnglish (US)
Pages (from-to)e33-e40
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume119
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Thalassemia
beta-Thalassemia
Hemoglobinopathies
Southeastern Asia
Inborn Genetic Diseases
Disease Management
Iran
Population Groups
Routine Diagnostic Tests
Oceans and Seas
Incidence
Therapeutics
Population

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Radiology Nuclear Medicine and imaging
  • Dentistry (miscellaneous)

Cite this

Craniofacial manifestations of β-thalassemia major. / Javid, Bahram; Said-Al-Naief, Nasser.

In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 119, No. 1, 01.01.2015, p. e33-e40.

Research output: Contribution to journalArticle

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