Cranial neuropathy following curative chemotherapy and radiotherapy for carcinoma of the nasopharynx

Matt Y. Kang, John Holland, Kenneth Stevens

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Cranial nerve damage following head and neck radiotherapy is an unusual event. Cranial neuropathy following concurrent chemotherapy and radiotherapy is unreported. The authors report a case of a 54-year-old man treated with curative chemotherapy and radiotherapy for a stage III nasopharyngeal carcinoma who developed an unilateral hypoglossal nerve palsy five years after therapy. Follow-up examination and magnetic resonance imaging (MRI) show no evidence of recurrent disease. Hypoglossal nerve injury occurring after head and neck radiotherapy is an indirect effect due to progressive soft tissue fibrosis and loss of vascularity. This process develops over years leading to nerve entrapment and permanent damage. Cranial nerve palsies, including damage to the hypoglossal nerve, can develop years after therapy with no evidence of tumour recurrence. Chemotherapy and radiotherapy have improved progression-free and overall survival in advanced nasopharyngeal cancer. As more patients achieve long-term tumour control following chemotherapy and radiotherapy, we must be cognizant of potential late injury to cranial nerves.

Original languageEnglish (US)
Pages (from-to)308-310
Number of pages3
JournalJournal of Laryngology and Otology
Volume114
Issue number4
StatePublished - 2000

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Cranial Nerve Diseases
Nasopharynx
Radiotherapy
Carcinoma
Drug Therapy
Hypoglossal Nerve Injuries
Hypoglossal Nerve Diseases
Cranial Nerve Injuries
Neck
Head
Nasopharyngeal Neoplasms
Hypoglossal Nerve
Nerve Compression Syndromes
Cranial Nerves
Disease-Free Survival
Neoplasms
Fibrosis
Magnetic Resonance Imaging
Recurrence
Therapeutics

Keywords

  • Carcinoma
  • Cranial nerve diseases
  • Drug therapy
  • Nasopharyngeal neoplasms
  • Radiotherapy

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Cranial neuropathy following curative chemotherapy and radiotherapy for carcinoma of the nasopharynx. / Kang, Matt Y.; Holland, John; Stevens, Kenneth.

In: Journal of Laryngology and Otology, Vol. 114, No. 4, 2000, p. 308-310.

Research output: Contribution to journalArticle

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