Cranial MRI changes may precede symptoms in Hallervorden-Spatz syndrome

Susan J. Hayflick, Johann M. Penzien, Wolfgang Michl, Uzma M. Sharif, N. Paul Rosman, Patricia G. Wheeler

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Two families are presented in which siblings of children affected with Hallervorden-Spatz syndrome exhibited characteristic cranial magnetic resonance imaging changes before developing clinical features of the disease. Linkage to a major locus on chromosome 20p supported the diagnosis of Hallervorden-Spatz syndrome. In some patients with Hallervorden-Spatz syndrome, iron is radiographically evident before the onset of clinical symptoms.

Original languageEnglish (US)
Pages (from-to)166-169
Number of pages4
JournalPediatric Neurology
Volume25
Issue number2
DOIs
StatePublished - Sep 21 2001

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Hayflick, S. J., Penzien, J. M., Michl, W., Sharif, U. M., Rosman, N. P., & Wheeler, P. G. (2001). Cranial MRI changes may precede symptoms in Hallervorden-Spatz syndrome. Pediatric Neurology, 25(2), 166-169. https://doi.org/10.1016/S0887-8994(01)00296-X