Cranial dystonia: Double-blind crossover study of anticholinergics

John G. Nutt; John P. Hammerstad; Pat deGarmo; Julie Carter

doi:10.1212/wnl.34.2.215

Cranial dystonia: Double-blind crossover study of anticholinergics

John G. Nutt, John P. Hammerstad, Pat deGarmo, Julie Carter

Neurology

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

In patients with cranial dystonia, we compared the effects of central anticholinergic, peripheral anticholinergic, and placebo treatments in a double-blind crossover study. One of the nine patients who completed the study improved markedly with central anticholinergic therapy. The three treatments were indistinguishable in the other eight patients except for the higher incidence of central and peripheral anticholinergic side effects with trihexyphenidyl.

Original language	English (US)
Pages (from-to)	215-517
Number of pages	303
Journal	Neurology
Volume	34
Issue number	2
DOIs	https://doi.org/10.1212/wnl.34.2.215
State	Published - Feb 1984

ASJC Scopus subject areas

Clinical Neurology

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abstract = "In patients with cranial dystonia, we compared the effects of central anticholinergic, peripheral anticholinergic, and placebo treatments in a double-blind crossover study. One of the nine patients who completed the study improved markedly with central anticholinergic therapy. The three treatments were indistinguishable in the other eight patients except for the higher incidence of central and peripheral anticholinergic side effects with trihexyphenidyl.",

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AB - In patients with cranial dystonia, we compared the effects of central anticholinergic, peripheral anticholinergic, and placebo treatments in a double-blind crossover study. One of the nine patients who completed the study improved markedly with central anticholinergic therapy. The three treatments were indistinguishable in the other eight patients except for the higher incidence of central and peripheral anticholinergic side effects with trihexyphenidyl.

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Cranial dystonia: Double-blind crossover study of anticholinergics

Abstract

ASJC Scopus subject areas

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