Covid-19 vaccination-associated myocarditis in adolescents

Supriya S. Jain, Jeremy M. Steele, Brian Fonseca, Sihong Huang, Sanket Shah, Shiraz A. Maskatia, Sujatha Buddhe, Nilanjana Misra, Preeti Ramachandran, Lasya Gaur, Parham Eshtehardi, Shafkat Anwar, Neeru Kaushik, Frank Han, Nita Ray Chaudhuri, Lars Grosse-Wortmann

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


OBJECTIVES: In this study, we aimed to characterize the clinical presentation, short-term prognosis, and myocardial tissue changes as noted on cardiovascular magnetic resonance (CMR) or cardiac MRI in pediatric patients with coronavirus disease 2019 vaccinationassociated myocarditis (C-VAM). METHODS: In this retrospective multicenter study across 16 US hospitals, patients <21 years of age with a diagnosis of C-VAM were included and compared with a cohort with multisystem inflammatory syndrome in children. Younger children with C-VAM were compared with older adolescents. RESULTS: Sixty-three patients with a mean age of 15.6 years were included 92% were male. All had received a messenger RNA vaccine and, except for one, presented after the second dose. Four patients had significant dysrhythmia 14% had mild left ventricular dysfunction on echocardiography, which resolved on discharge88% met the diagnostic CMR Lake Louise criteria for myocarditis. Myocardial injury as evidenced by late gadolinium enhancement on CMR was more prevalent in comparison with multisystem inflammatory syndrome in children. None of the patients required inotropic, mechanical, or circulatory support. There were no deaths. Follow-up data obtained in 86% of patients at a mean of 35 days revealed resolution of symptoms, arrhythmias, and ventricular dysfunction. CONCLUSIONS: Clinical characteristics and early outcomes are similar between the different pediatric age groups in C-VAM. The hospital course is mild, with quick clinical recovery and excellent short-term outcomes. Myocardial injury and edema are noted on CMR. Close followup and further studies are needed to understand the long-term implications and mechanism of these myocardial tissue changes.

Original languageEnglish (US)
Article numbere2021053427
Issue number5
StatePublished - Nov 1 2021

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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