COVID-19 coagulopathy and thrombosis: Analysis of hospital protocols in response to the rapidly evolving pandemic

the Hospital Medicine Reengineering Network (HOMERuN)

Research output: Contribution to journalLetterpeer-review

1 Scopus citations

Abstract

As the Coronavirus disease 2019 (COVID-19) pandemic spread to the US, so too did descriptions of an associated coagulopathy and thrombotic complications. Hospitals created institutional protocols for inpatient management of COVID-19 coagulopathy and thrombosis in response to this developing data. We collected and analyzed protocols from 21 US academic medical centers developed between January and May 2020. We found greatest consensus on recommendations for heparin-based pharmacologic venous thromboembolism (VTE) prophylaxis in COVID-19 patients without contraindications. Protocols differed regarding incorporation of D-dimer tests, dosing of VTE prophylaxis, indications for post-discharge pharmacologic VTE prophylaxis, how to evaluate for VTE, and the use of empiric therapeutic anticoagulation. These findings support ongoing efforts to establish international, evidence-based guidelines.

Original languageEnglish (US)
Pages (from-to)355-358
Number of pages4
JournalThrombosis research
Volume196
DOIs
StatePublished - Dec 2020
Externally publishedYes

Keywords

  • Anticoagulation
  • Coagulopathy
  • Coronavirus
  • Deep vein thrombosis (DVT)
  • Pulmonary embolism (PE)
  • Thrombosis
  • Venous thromboembolism (VTE)

ASJC Scopus subject areas

  • Hematology

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