Course of depressive symptoms and treatment in the longitudinal assessment of bariatric surgery (LABS-2) study

James E. Mitchell, Wendy C. King, Jia Yuh Chen, Michael J. Devlin, David Flum, Luis Garcia, William Inabet, John R. Pender, Melissa A. Kalarchian, Saurabh Khandelwal, Marsha D. Marcus, Beth Schrope, Gladys Strain, Bruce Wolfe, Susan Yanovski

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Abstract

Objective To examine changes in depressive symptoms and treatment in the first 3 years following bariatric surgery. Methods The longitudinal assessment of bariatric surgery-2 (LABS-2) is an observational cohort study of adults (n = 2,458) who underwent a bariatric surgical procedure at 1 of 10 US hospitals between 2006 and 2009. This study includes 2,148 participants who completed the Beck depression inventory (BDI) at baseline and ≥ one follow-up visit in years 1-3. Results At baseline, 40.4% self-reported treatment for depression. At least mild depressive symptoms (BDI score ≥ 10) were reported by 28.3%; moderate (BDI score 19-29) and severe (BDI score ≥30) symptoms were uncommon (4.2 and 0.5%, respectively). Mild-to-severe depressive symptoms independently increased the odds (OR = 1.75; P = 0.03) of a major adverse event within 30 days of surgery. Compared with baseline, symptom severity was significantly lower at all follow-up time points (e.g., mild-to-severe symptomatology was 8.9%, 6 months; 8.4%, 1year; 12.2%, 2 years; 15.6%, 3 years; ps <0.001), but increased between 1 and 3 years postoperatively (P <0.01). Change in depressive symptoms was significantly related to change in body mass index (r = 0.42; P <0001). Conclusion Bariatric surgery has a positive impact on depressive features. However, data suggest some deterioration in improvement after the first postoperative year. LABS-2, #NCT00465829, http://www. clinicaltrials.gov/ct2/show/NCT00465829.

Original languageEnglish (US)
Pages (from-to)1799-1806
Number of pages8
JournalObesity
Volume22
Issue number8
DOIs
StatePublished - 2014

Fingerprint

Bariatric Surgery
Depression
Equipment and Supplies
Therapeutics
Ambulatory Surgical Procedures
Observational Studies
Body Mass Index
Cohort Studies

Keywords

  • antidepressant medication
  • depression
  • laparoscopic adjustable gastric band
  • Roux-en-Y gastric bypass
  • severe obesity
  • treatment
  • weight loss

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Mitchell, J. E., King, W. C., Chen, J. Y., Devlin, M. J., Flum, D., Garcia, L., ... Yanovski, S. (2014). Course of depressive symptoms and treatment in the longitudinal assessment of bariatric surgery (LABS-2) study. Obesity, 22(8), 1799-1806. https://doi.org/10.1002/oby.20738

Course of depressive symptoms and treatment in the longitudinal assessment of bariatric surgery (LABS-2) study. / Mitchell, James E.; King, Wendy C.; Chen, Jia Yuh; Devlin, Michael J.; Flum, David; Garcia, Luis; Inabet, William; Pender, John R.; Kalarchian, Melissa A.; Khandelwal, Saurabh; Marcus, Marsha D.; Schrope, Beth; Strain, Gladys; Wolfe, Bruce; Yanovski, Susan.

In: Obesity, Vol. 22, No. 8, 2014, p. 1799-1806.

Research output: Contribution to journalArticle

Mitchell, JE, King, WC, Chen, JY, Devlin, MJ, Flum, D, Garcia, L, Inabet, W, Pender, JR, Kalarchian, MA, Khandelwal, S, Marcus, MD, Schrope, B, Strain, G, Wolfe, B & Yanovski, S 2014, 'Course of depressive symptoms and treatment in the longitudinal assessment of bariatric surgery (LABS-2) study', Obesity, vol. 22, no. 8, pp. 1799-1806. https://doi.org/10.1002/oby.20738
Mitchell, James E. ; King, Wendy C. ; Chen, Jia Yuh ; Devlin, Michael J. ; Flum, David ; Garcia, Luis ; Inabet, William ; Pender, John R. ; Kalarchian, Melissa A. ; Khandelwal, Saurabh ; Marcus, Marsha D. ; Schrope, Beth ; Strain, Gladys ; Wolfe, Bruce ; Yanovski, Susan. / Course of depressive symptoms and treatment in the longitudinal assessment of bariatric surgery (LABS-2) study. In: Obesity. 2014 ; Vol. 22, No. 8. pp. 1799-1806.
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abstract = "Objective To examine changes in depressive symptoms and treatment in the first 3 years following bariatric surgery. Methods The longitudinal assessment of bariatric surgery-2 (LABS-2) is an observational cohort study of adults (n = 2,458) who underwent a bariatric surgical procedure at 1 of 10 US hospitals between 2006 and 2009. This study includes 2,148 participants who completed the Beck depression inventory (BDI) at baseline and ≥ one follow-up visit in years 1-3. Results At baseline, 40.4{\%} self-reported treatment for depression. At least mild depressive symptoms (BDI score ≥ 10) were reported by 28.3{\%}; moderate (BDI score 19-29) and severe (BDI score ≥30) symptoms were uncommon (4.2 and 0.5{\%}, respectively). Mild-to-severe depressive symptoms independently increased the odds (OR = 1.75; P = 0.03) of a major adverse event within 30 days of surgery. Compared with baseline, symptom severity was significantly lower at all follow-up time points (e.g., mild-to-severe symptomatology was 8.9{\%}, 6 months; 8.4{\%}, 1year; 12.2{\%}, 2 years; 15.6{\%}, 3 years; ps <0.001), but increased between 1 and 3 years postoperatively (P <0.01). Change in depressive symptoms was significantly related to change in body mass index (r = 0.42; P <0001). Conclusion Bariatric surgery has a positive impact on depressive features. However, data suggest some deterioration in improvement after the first postoperative year. LABS-2, #NCT00465829, http://www. clinicaltrials.gov/ct2/show/NCT00465829.",
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AU - King, Wendy C.

AU - Chen, Jia Yuh

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AU - Flum, David

AU - Garcia, Luis

AU - Inabet, William

AU - Pender, John R.

AU - Kalarchian, Melissa A.

AU - Khandelwal, Saurabh

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N2 - Objective To examine changes in depressive symptoms and treatment in the first 3 years following bariatric surgery. Methods The longitudinal assessment of bariatric surgery-2 (LABS-2) is an observational cohort study of adults (n = 2,458) who underwent a bariatric surgical procedure at 1 of 10 US hospitals between 2006 and 2009. This study includes 2,148 participants who completed the Beck depression inventory (BDI) at baseline and ≥ one follow-up visit in years 1-3. Results At baseline, 40.4% self-reported treatment for depression. At least mild depressive symptoms (BDI score ≥ 10) were reported by 28.3%; moderate (BDI score 19-29) and severe (BDI score ≥30) symptoms were uncommon (4.2 and 0.5%, respectively). Mild-to-severe depressive symptoms independently increased the odds (OR = 1.75; P = 0.03) of a major adverse event within 30 days of surgery. Compared with baseline, symptom severity was significantly lower at all follow-up time points (e.g., mild-to-severe symptomatology was 8.9%, 6 months; 8.4%, 1year; 12.2%, 2 years; 15.6%, 3 years; ps <0.001), but increased between 1 and 3 years postoperatively (P <0.01). Change in depressive symptoms was significantly related to change in body mass index (r = 0.42; P <0001). Conclusion Bariatric surgery has a positive impact on depressive features. However, data suggest some deterioration in improvement after the first postoperative year. LABS-2, #NCT00465829, http://www. clinicaltrials.gov/ct2/show/NCT00465829.

AB - Objective To examine changes in depressive symptoms and treatment in the first 3 years following bariatric surgery. Methods The longitudinal assessment of bariatric surgery-2 (LABS-2) is an observational cohort study of adults (n = 2,458) who underwent a bariatric surgical procedure at 1 of 10 US hospitals between 2006 and 2009. This study includes 2,148 participants who completed the Beck depression inventory (BDI) at baseline and ≥ one follow-up visit in years 1-3. Results At baseline, 40.4% self-reported treatment for depression. At least mild depressive symptoms (BDI score ≥ 10) were reported by 28.3%; moderate (BDI score 19-29) and severe (BDI score ≥30) symptoms were uncommon (4.2 and 0.5%, respectively). Mild-to-severe depressive symptoms independently increased the odds (OR = 1.75; P = 0.03) of a major adverse event within 30 days of surgery. Compared with baseline, symptom severity was significantly lower at all follow-up time points (e.g., mild-to-severe symptomatology was 8.9%, 6 months; 8.4%, 1year; 12.2%, 2 years; 15.6%, 3 years; ps <0.001), but increased between 1 and 3 years postoperatively (P <0.01). Change in depressive symptoms was significantly related to change in body mass index (r = 0.42; P <0001). Conclusion Bariatric surgery has a positive impact on depressive features. However, data suggest some deterioration in improvement after the first postoperative year. LABS-2, #NCT00465829, http://www. clinicaltrials.gov/ct2/show/NCT00465829.

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