Costimulation of Th17 cells: Adding fuel or putting out the fire in the inflamed gut?

Zili Zhang, James (Jim) Rosenbaum, Wenwei Zhong, Carmen Lim, David J. Hinrichs

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Inflammatory bowel disease, typified by Crohn's disease and ulcerative colitis, is a common disorder characterized by recurrent and serious inflammation of the gastrointestinal tract. It is well documented that T cells play a pivotal role in the development of inflammatory bowel disease. Th17 cells are a unique T cell subpopulation implicated in inflammatory bowel disease and many other autoimmune/inflammatory diseases. However, the regulatory mechanism of Th17 activation and proliferation has not been defined completely. Recent studies have shown that the ligation of several costimulatory receptor-ligand pairs contributes to the activation, differentiation, and proliferation of T lymphocytes including the Th17 subset. In this review, we will discuss the emerging evidence on the role of Th17 cells in inflammatory bowel disease pathogenesis as well as the effect of costimulatory molecules on Th17 development and consider if the need for such costimulation of T lymphocytes provides a target for the development of novel therapeutic strategy.

Original languageEnglish (US)
Pages (from-to)55-70
Number of pages16
JournalSeminars in Immunopathology
Volume32
Issue number1
DOIs
StatePublished - Mar 2010

Fingerprint

Th17 Cells
Inflammatory Bowel Diseases
T-Lymphocytes
Ulcerative Colitis
Crohn Disease
Autoimmune Diseases
Ligation
Gastrointestinal Tract
Ligands
Inflammation
Therapeutics

Keywords

  • CD4+ T cells
  • Costimulatory molecules
  • Crohn's disease
  • Inflammatory bowel disease
  • Th17 cells
  • Ulcerative colitis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Costimulation of Th17 cells : Adding fuel or putting out the fire in the inflamed gut? / Zhang, Zili; Rosenbaum, James (Jim); Zhong, Wenwei; Lim, Carmen; Hinrichs, David J.

In: Seminars in Immunopathology, Vol. 32, No. 1, 03.2010, p. 55-70.

Research output: Contribution to journalArticle

Zhang, Zili ; Rosenbaum, James (Jim) ; Zhong, Wenwei ; Lim, Carmen ; Hinrichs, David J. / Costimulation of Th17 cells : Adding fuel or putting out the fire in the inflamed gut?. In: Seminars in Immunopathology. 2010 ; Vol. 32, No. 1. pp. 55-70.
@article{45e0ebf466134cecba4a41789164fa18,
title = "Costimulation of Th17 cells: Adding fuel or putting out the fire in the inflamed gut?",
abstract = "Inflammatory bowel disease, typified by Crohn's disease and ulcerative colitis, is a common disorder characterized by recurrent and serious inflammation of the gastrointestinal tract. It is well documented that T cells play a pivotal role in the development of inflammatory bowel disease. Th17 cells are a unique T cell subpopulation implicated in inflammatory bowel disease and many other autoimmune/inflammatory diseases. However, the regulatory mechanism of Th17 activation and proliferation has not been defined completely. Recent studies have shown that the ligation of several costimulatory receptor-ligand pairs contributes to the activation, differentiation, and proliferation of T lymphocytes including the Th17 subset. In this review, we will discuss the emerging evidence on the role of Th17 cells in inflammatory bowel disease pathogenesis as well as the effect of costimulatory molecules on Th17 development and consider if the need for such costimulation of T lymphocytes provides a target for the development of novel therapeutic strategy.",
keywords = "CD4+ T cells, Costimulatory molecules, Crohn's disease, Inflammatory bowel disease, Th17 cells, Ulcerative colitis",
author = "Zili Zhang and Rosenbaum, {James (Jim)} and Wenwei Zhong and Carmen Lim and Hinrichs, {David J.}",
year = "2010",
month = "3",
doi = "10.1007/s00281-009-0190-3",
language = "English (US)",
volume = "32",
pages = "55--70",
journal = "Seminars in Immunopathology",
issn = "1863-2297",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Costimulation of Th17 cells

T2 - Adding fuel or putting out the fire in the inflamed gut?

AU - Zhang, Zili

AU - Rosenbaum, James (Jim)

AU - Zhong, Wenwei

AU - Lim, Carmen

AU - Hinrichs, David J.

PY - 2010/3

Y1 - 2010/3

N2 - Inflammatory bowel disease, typified by Crohn's disease and ulcerative colitis, is a common disorder characterized by recurrent and serious inflammation of the gastrointestinal tract. It is well documented that T cells play a pivotal role in the development of inflammatory bowel disease. Th17 cells are a unique T cell subpopulation implicated in inflammatory bowel disease and many other autoimmune/inflammatory diseases. However, the regulatory mechanism of Th17 activation and proliferation has not been defined completely. Recent studies have shown that the ligation of several costimulatory receptor-ligand pairs contributes to the activation, differentiation, and proliferation of T lymphocytes including the Th17 subset. In this review, we will discuss the emerging evidence on the role of Th17 cells in inflammatory bowel disease pathogenesis as well as the effect of costimulatory molecules on Th17 development and consider if the need for such costimulation of T lymphocytes provides a target for the development of novel therapeutic strategy.

AB - Inflammatory bowel disease, typified by Crohn's disease and ulcerative colitis, is a common disorder characterized by recurrent and serious inflammation of the gastrointestinal tract. It is well documented that T cells play a pivotal role in the development of inflammatory bowel disease. Th17 cells are a unique T cell subpopulation implicated in inflammatory bowel disease and many other autoimmune/inflammatory diseases. However, the regulatory mechanism of Th17 activation and proliferation has not been defined completely. Recent studies have shown that the ligation of several costimulatory receptor-ligand pairs contributes to the activation, differentiation, and proliferation of T lymphocytes including the Th17 subset. In this review, we will discuss the emerging evidence on the role of Th17 cells in inflammatory bowel disease pathogenesis as well as the effect of costimulatory molecules on Th17 development and consider if the need for such costimulation of T lymphocytes provides a target for the development of novel therapeutic strategy.

KW - CD4+ T cells

KW - Costimulatory molecules

KW - Crohn's disease

KW - Inflammatory bowel disease

KW - Th17 cells

KW - Ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=77949654443&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949654443&partnerID=8YFLogxK

U2 - 10.1007/s00281-009-0190-3

DO - 10.1007/s00281-009-0190-3

M3 - Article

C2 - 20119686

AN - SCOPUS:77949654443

VL - 32

SP - 55

EP - 70

JO - Seminars in Immunopathology

JF - Seminars in Immunopathology

SN - 1863-2297

IS - 1

ER -