Cost-effectiveness analyses in gynecologic oncology: Methodological quality and trends

Michael R. Manuel, Lee May Chen, Aaron Caughey, Leslee L. Subak

Research output: Contribution to journalArticle

12 Scopus citations


Objective. To evaluate methodological quality and trends of cost-effectiveness analyses (CEA) published in gynecologic oncology. Methods. A medical literature search of articles from 1966 through 2002 was performed to identify original, English-language articles that included economic analyses in gynecologic oncology. We included articles that were cost-effectiveness or cost-benefit analyses or performed these analyses as part of their study. Ten methodological principles that should be incorporated in CEAs were assessed for each study. Each article was given a score of 0, 1, or 2 for each of the 10 methodological principles (max score = 20). Data were analyzed using the Student t test, ANOVA, and linear regression. Results. We screened 693 articles to identify 68 that met our inclusion criteria. The articles focused on cervical cancer (n = 53; 78%), ovarian cancer (n = 11; 16%), uterine cancer (n = 2; 3%), and general perioperative care (n = 2; 3%). The mean (±SD) methodological principle score was 16.1 (±4.1) and we observed a significant improvement in the total score over time (P = 0.01). Primary CEA's (CEA identified as the objective of the study) were of higher quality than secondary CEA's (primary objective of the study was not CEA but CEA was included in the study; total scores 18.2 vs. 11.6, respectively; P

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalGynecologic Oncology
Issue number1
Publication statusPublished - Apr 2004
Externally publishedYes



  • Cost-benefit analysis
  • Economics
  • Gynecology-economics

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

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