Cortisol stimulation of growth hormone production by human pituitary tissue in culture

William E. Bridson, Peter O. Kohler

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Human growth hormone (HGH) production increased as much as 30-fold after the addition of 5×10-6 to 5×10-7M cortisol to explant cultures of pituitary adenomas from acromegalic patients. Increases in HGH production were also noted in 2 of 4 cultures of normal human pituitaries. This study extends to the human the previously described stimulatory action of cortisol on growth hormone production in cultures of normal monkey and rat pituitary tumor cells.

Original languageEnglish (US)
Pages (from-to)538-540
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume30
Issue number4
DOIs
StatePublished - Jan 1 1970

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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