Cortisol production rate in childhood and adolescence

Barbara L. Linder, Nora V. Esteban, Alfred L. Yergey, Jorg C. Winterer, Donald (Lynn) Loriaux, Fernando Cassorla

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

We studied the daily cortisol production rate in 33 normal children and adolescents, using a stable isotope-dilution technique employing high-performance liquid chromatography-mass spectrometry. Two indwelling intravenous catheters were inserted and tracer 9,12,12-2H3-cortisol (deuterated cortisol) was infused continuously for 30 hours. After 6 hours of tracer infusion to allow for equilibration, blood was obtained every 20 minutes for 24 hours. The mean (±SD) cortisol production rate was 9.5±2.5 mg/day (6.8±1.9 mg/m2/day). Cortisol production rate did not vary with sex or pubertal stage. These results suggest that the cortisol production rate in children and adolescents is significantly lower than previously estimated.

Original languageEnglish (US)
Pages (from-to)892-896
Number of pages5
JournalThe Journal of Pediatrics
Volume117
Issue number6
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Hydrocortisone
Indicator Dilution Techniques
Indwelling Catheters
Isotopes
Mass Spectrometry
High Pressure Liquid Chromatography

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Linder, B. L., Esteban, N. V., Yergey, A. L., Winterer, J. C., Loriaux, D. L., & Cassorla, F. (1990). Cortisol production rate in childhood and adolescence. The Journal of Pediatrics, 117(6), 892-896. https://doi.org/10.1016/S0022-3476(05)80128-3

Cortisol production rate in childhood and adolescence. / Linder, Barbara L.; Esteban, Nora V.; Yergey, Alfred L.; Winterer, Jorg C.; Loriaux, Donald (Lynn); Cassorla, Fernando.

In: The Journal of Pediatrics, Vol. 117, No. 6, 1990, p. 892-896.

Research output: Contribution to journalArticle

Linder, BL, Esteban, NV, Yergey, AL, Winterer, JC, Loriaux, DL & Cassorla, F 1990, 'Cortisol production rate in childhood and adolescence', The Journal of Pediatrics, vol. 117, no. 6, pp. 892-896. https://doi.org/10.1016/S0022-3476(05)80128-3
Linder, Barbara L. ; Esteban, Nora V. ; Yergey, Alfred L. ; Winterer, Jorg C. ; Loriaux, Donald (Lynn) ; Cassorla, Fernando. / Cortisol production rate in childhood and adolescence. In: The Journal of Pediatrics. 1990 ; Vol. 117, No. 6. pp. 892-896.
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