TY - JOUR
T1 - Cortisol induction of growth hormone synthesis in a clonal line of rat pituitary tumor cells in culture
AU - Kohler, Peter O.
AU - Frohman, Lawrence A.
AU - Bridson, William E.
AU - Vanha-Perttula, Tapani
AU - Hammond, James M.
PY - 1969
Y1 - 1969
N2 - Growth hormone synthesis increased markedly after addition of glucocorticoids at physiological concentrations to cultures of the GH 1 line of rat pituitary tumor cells. Stimulation of hormone protein synthesis by corticosteroids was selective, since (i) the rate of hormone synthesis increased while total protein synthesis decreased, and (ii) cortisol analogs, biologically inactive metabolites, and sex steroids did not induce growth hormone synthesis.
AB - Growth hormone synthesis increased markedly after addition of glucocorticoids at physiological concentrations to cultures of the GH 1 line of rat pituitary tumor cells. Stimulation of hormone protein synthesis by corticosteroids was selective, since (i) the rate of hormone synthesis increased while total protein synthesis decreased, and (ii) cortisol analogs, biologically inactive metabolites, and sex steroids did not induce growth hormone synthesis.
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U2 - 10.1126/science.166.3905.633
DO - 10.1126/science.166.3905.633
M3 - Article
C2 - 5823301
AN - SCOPUS:0014697594
SN - 0036-8075
VL - 166
SP - 633
EP - 634
JO - Science
JF - Science
IS - 3905
ER -