Cortisol induction of growth hormone synthesis in a clonal line of rat pituitary tumor cells in culture

Peter Kohler, Lawrence A. Frohman, William E. Bridson, Tapani Vanha-Perttula, James M. Hammond

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Growth hormone synthesis increased markedly after addition of glucocorticoids at physiological concentrations to cultures of the GH 1 line of rat pituitary tumor cells. Stimulation of hormone protein synthesis by corticosteroids was selective, since (i) the rate of hormone synthesis increased while total protein synthesis decreased, and (ii) cortisol analogs, biologically inactive metabolites, and sex steroids did not induce growth hormone synthesis.

Original languageEnglish (US)
Pages (from-to)633-634
Number of pages2
JournalScience
Volume166
Issue number3905
StatePublished - 1969
Externally publishedYes

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Pituitary Neoplasms
Growth Hormone
Hydrocortisone
Cell Culture Techniques
Hormones
Glucocorticoids
Adrenal Cortex Hormones
Proteins
Steroids

ASJC Scopus subject areas

  • General

Cite this

Kohler, P., Frohman, L. A., Bridson, W. E., Vanha-Perttula, T., & Hammond, J. M. (1969). Cortisol induction of growth hormone synthesis in a clonal line of rat pituitary tumor cells in culture. Science, 166(3905), 633-634.

Cortisol induction of growth hormone synthesis in a clonal line of rat pituitary tumor cells in culture. / Kohler, Peter; Frohman, Lawrence A.; Bridson, William E.; Vanha-Perttula, Tapani; Hammond, James M.

In: Science, Vol. 166, No. 3905, 1969, p. 633-634.

Research output: Contribution to journalArticle

Kohler, P, Frohman, LA, Bridson, WE, Vanha-Perttula, T & Hammond, JM 1969, 'Cortisol induction of growth hormone synthesis in a clonal line of rat pituitary tumor cells in culture', Science, vol. 166, no. 3905, pp. 633-634.
Kohler P, Frohman LA, Bridson WE, Vanha-Perttula T, Hammond JM. Cortisol induction of growth hormone synthesis in a clonal line of rat pituitary tumor cells in culture. Science. 1969;166(3905):633-634.
Kohler, Peter ; Frohman, Lawrence A. ; Bridson, William E. ; Vanha-Perttula, Tapani ; Hammond, James M. / Cortisol induction of growth hormone synthesis in a clonal line of rat pituitary tumor cells in culture. In: Science. 1969 ; Vol. 166, No. 3905. pp. 633-634.
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