TY - JOUR
T1 - Corticotropin-releasing hormone-related peptides and receptors
T2 - Emergent regulators of cardiovascular adaptations to stress
AU - Coste, Sarah C.
AU - Quintos, Robert F.
AU - Stenzel-Poore, Mary P.
N1 - Funding Information:
The authors wish to thank Kurt Heldwein and Michael Silberbach for sharing their unpublished studies central to the theme of this review. This work was supported by National Institutes of Health Grant HL-55512 to M.S-P. and an American Heart Association Fellowship to S.C.C.
PY - 2002
Y1 - 2002
N2 - Since its discovery 2 decades ago, potent effects of corticotropin-releasing hormone (CRH) on the heart and vasculature have been consistently observed. The recent discoveries of novel CRH-related peptides residing in the heart and a distinct cardiac CRH receptor (CRH-R2), have renewed interest in the role of the CRH family on cardiovascular function. This review highlights the emerging view of a peripheral, cardiac CRH system and its potential relevance in mediating the adaptive response of the heart to stress. (Trends Cardiovascular Med 2002;12:176-182).
AB - Since its discovery 2 decades ago, potent effects of corticotropin-releasing hormone (CRH) on the heart and vasculature have been consistently observed. The recent discoveries of novel CRH-related peptides residing in the heart and a distinct cardiac CRH receptor (CRH-R2), have renewed interest in the role of the CRH family on cardiovascular function. This review highlights the emerging view of a peripheral, cardiac CRH system and its potential relevance in mediating the adaptive response of the heart to stress. (Trends Cardiovascular Med 2002;12:176-182).
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U2 - 10.1016/S1050-1738(02)00157-3
DO - 10.1016/S1050-1738(02)00157-3
M3 - Review article
C2 - 12069758
AN - SCOPUS:0036274650
SN - 1050-1738
VL - 12
SP - 176
EP - 182
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 4
ER -