Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease

Eve Van Cauter, Florian Holsboer, Brian Harris, D. R. Thomas, Richard P. Levy, Philip W. Gold, Mitchel A. Kling, Joseph R. Calabrese, Robert M. Post, Alec Roy, Lynnette K. Nieman, Gordon B. Cutler, D. Lynn Loriaux, George P. Chrousos

Research output: Contribution to journalLetterpeer-review

2 Scopus citations

Abstract

To the Editor: The report by Gold and colleagues (May 22 issue)1 indicated that the plasma ACTH response to ovine corticotropin-releasing hormone stimulation can be helpful in the differential diagnosis of two conditions of hypercortisolism — the depressive phase of primary affective disorder and Cushing's disease. This conclusion was based on the finding that the response to ovine corticotropin-releasing hormone appeared attenuated in patients with depression and exaggerated in patients with Cushing's disease. In particular, the “peak ACTH response,” defined as the highest level of plasma ACTH occurring within one hour after a bolus injection of 1 μg of ovine….

Original languageEnglish (US)
Pages (from-to)217-219
Number of pages3
JournalNew England Journal of Medicine
Volume316
Issue number4
DOIs
StatePublished - Jan 22 1987

ASJC Scopus subject areas

  • Medicine(all)

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