Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease

Eve Van Cauter, Florian Holsboer, Brian Harris, D. R. Thomas, Richard P. Levy, Philip W. Gold, Mitchel A. Kling, Joseph R. Calabrese, Robert M. Post, Alec Roy, Lynnette K. Nieman, Gordon B. Cutler, Donald (Lynn) Loriaux, George P. Chrousos

Research output: Contribution to journalLetter

2 Citations (Scopus)

Abstract

To the Editor: The report by Gold and colleagues (May 22 issue)1 indicated that the plasma ACTH response to ovine corticotropin-releasing hormone stimulation can be helpful in the differential diagnosis of two conditions of hypercortisolism — the depressive phase of primary affective disorder and Cushing's disease. This conclusion was based on the finding that the response to ovine corticotropin-releasing hormone appeared attenuated in patients with depression and exaggerated in patients with Cushing's disease. In particular, the “peak ACTH response,” defined as the highest level of plasma ACTH occurring within one hour after a bolus injection of 1 μg of ovine….

Original languageEnglish (US)
Pages (from-to)217-219
Number of pages3
JournalNew England Journal of Medicine
Volume316
Issue number4
DOIs
StatePublished - Jan 22 1987
Externally publishedYes

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Pituitary ACTH Hypersecretion
Cushing Syndrome
Corticotropin-Releasing Hormone
Adrenocorticotropic Hormone
Sheep
Depression
Mood Disorders
Gold
Differential Diagnosis
Injections

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Van Cauter, E., Holsboer, F., Harris, B., Thomas, D. R., Levy, R. P., Gold, P. W., ... Chrousos, G. P. (1987). Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease. New England Journal of Medicine, 316(4), 217-219. https://doi.org/10.1056/NEJM198701223160413

Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease. / Van Cauter, Eve; Holsboer, Florian; Harris, Brian; Thomas, D. R.; Levy, Richard P.; Gold, Philip W.; Kling, Mitchel A.; Calabrese, Joseph R.; Post, Robert M.; Roy, Alec; Nieman, Lynnette K.; Cutler, Gordon B.; Loriaux, Donald (Lynn); Chrousos, George P.

In: New England Journal of Medicine, Vol. 316, No. 4, 22.01.1987, p. 217-219.

Research output: Contribution to journalLetter

Van Cauter, E, Holsboer, F, Harris, B, Thomas, DR, Levy, RP, Gold, PW, Kling, MA, Calabrese, JR, Post, RM, Roy, A, Nieman, LK, Cutler, GB, Loriaux, DL & Chrousos, GP 1987, 'Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease', New England Journal of Medicine, vol. 316, no. 4, pp. 217-219. https://doi.org/10.1056/NEJM198701223160413
Van Cauter, Eve ; Holsboer, Florian ; Harris, Brian ; Thomas, D. R. ; Levy, Richard P. ; Gold, Philip W. ; Kling, Mitchel A. ; Calabrese, Joseph R. ; Post, Robert M. ; Roy, Alec ; Nieman, Lynnette K. ; Cutler, Gordon B. ; Loriaux, Donald (Lynn) ; Chrousos, George P. / Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease. In: New England Journal of Medicine. 1987 ; Vol. 316, No. 4. pp. 217-219.
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