Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease

Eve Van Cauter; Florian Holsboer; Brian Harris; D. R. Thomas; Richard P. Levy; Philip W. Gold; Mitchel A. Kling; Joseph R. Calabrese; Robert M. Post; Alec Roy; Lynnette K. Nieman; Gordon B. Cutler; D. Lynn Loriaux; George P. Chrousos

doi:10.1056/NEJM198701223160413

Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease

Eve Van Cauter, Florian Holsboer, Brian Harris, D. R. Thomas, Richard P. Levy, Philip W. Gold, Mitchel A. Kling, Joseph R. Calabrese, Robert M. Post, Alec Roy, Lynnette K. Nieman, Gordon B. Cutler, D. Lynn Loriaux, George P. Chrousos

Research output: Contribution to journal › Letter › peer-review

2 Scopus citations

Abstract

To the Editor: The report by Gold and colleagues (May 22 issue)¹ indicated that the plasma ACTH response to ovine corticotropin-releasing hormone stimulation can be helpful in the differential diagnosis of two conditions of hypercortisolism — the depressive phase of primary affective disorder and Cushing's disease. This conclusion was based on the finding that the response to ovine corticotropin-releasing hormone appeared attenuated in patients with depression and exaggerated in patients with Cushing's disease. In particular, the “peak ACTH response,” defined as the highest level of plasma ACTH occurring within one hour after a bolus injection of 1 μg of ovine….

Original language	English (US)
Pages (from-to)	217-219
Number of pages	3
Journal	New England Journal of Medicine
Volume	316
Issue number	4
DOIs	https://doi.org/10.1056/NEJM198701223160413
State	Published - Jan 22 1987
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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Van Cauter, E., Holsboer, F., Harris, B., Thomas, D. R., Levy, R. P., Gold, P. W., Kling, M. A., Calabrese, J. R., Post, R. M., Roy, A., Nieman, L. K., Cutler, G. B., Loriaux, D. L., & Chrousos, G. P. (1987). Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease. New England Journal of Medicine, 316(4), 217-219. https://doi.org/10.1056/NEJM198701223160413

Van Cauter, E, Holsboer, F, Harris, B, Thomas, DR, Levy, RP, Gold, PW, Kling, MA, Calabrese, JR, Post, RM, Roy, A, Nieman, LK, Cutler, GB, Loriaux, DL & Chrousos, GP 1987, 'Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease', New England Journal of Medicine, vol. 316, no. 4, pp. 217-219. https://doi.org/10.1056/NEJM198701223160413

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title = "Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease",

abstract = "To the Editor: The report by Gold and colleagues (May 22 issue)1 indicated that the plasma ACTH response to ovine corticotropin-releasing hormone stimulation can be helpful in the differential diagnosis of two conditions of hypercortisolism — the depressive phase of primary affective disorder and Cushing's disease. This conclusion was based on the finding that the response to ovine corticotropin-releasing hormone appeared attenuated in patients with depression and exaggerated in patients with Cushing's disease. In particular, the “peak ACTH response,” defined as the highest level of plasma ACTH occurring within one hour after a bolus injection of 1 μg of ovine….",

author = "{Van Cauter}, Eve and Florian Holsboer and Brian Harris and Thomas, {D. R.} and Levy, {Richard P.} and Gold, {Philip W.} and Kling, {Mitchel A.} and Calabrese, {Joseph R.} and Post, {Robert M.} and Alec Roy and Nieman, {Lynnette K.} and Cutler, {Gordon B.} and Loriaux, {D. Lynn} and Chrousos, {George P.}",

year = "1987",

month = jan,

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doi = "10.1056/NEJM198701223160413",

language = "English (US)",

volume = "316",

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journal = "New England Journal of Medicine",

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T1 - Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease

AU - Van Cauter, Eve

AU - Holsboer, Florian

AU - Harris, Brian

AU - Thomas, D. R.

AU - Levy, Richard P.

AU - Gold, Philip W.

AU - Kling, Mitchel A.

AU - Calabrese, Joseph R.

AU - Post, Robert M.

AU - Roy, Alec

AU - Nieman, Lynnette K.

AU - Cutler, Gordon B.

AU - Loriaux, D. Lynn

AU - Chrousos, George P.

PY - 1987/1/22

Y1 - 1987/1/22

N2 - To the Editor: The report by Gold and colleagues (May 22 issue)1 indicated that the plasma ACTH response to ovine corticotropin-releasing hormone stimulation can be helpful in the differential diagnosis of two conditions of hypercortisolism — the depressive phase of primary affective disorder and Cushing's disease. This conclusion was based on the finding that the response to ovine corticotropin-releasing hormone appeared attenuated in patients with depression and exaggerated in patients with Cushing's disease. In particular, the “peak ACTH response,” defined as the highest level of plasma ACTH occurring within one hour after a bolus injection of 1 μg of ovine….

AB - To the Editor: The report by Gold and colleagues (May 22 issue)1 indicated that the plasma ACTH response to ovine corticotropin-releasing hormone stimulation can be helpful in the differential diagnosis of two conditions of hypercortisolism — the depressive phase of primary affective disorder and Cushing's disease. This conclusion was based on the finding that the response to ovine corticotropin-releasing hormone appeared attenuated in patients with depression and exaggerated in patients with Cushing's disease. In particular, the “peak ACTH response,” defined as the highest level of plasma ACTH occurring within one hour after a bolus injection of 1 μg of ovine….

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Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease

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