Corticosterone increases severity of acute withdrawal from ethanol, pentobarbital, and diazepam in mice

A. J. Roberts, John Jr Crabbe, L. D. Keith

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

It has been suggested that withdrawal from several subclasses of central nervous system (CNS) depressants involves common underlying mechanisms. For example, mice genetically selected for severe ethanol withdrawal convulsions (Withdrawal Seizure Prone or WSP) have also been found to express severe withdrawal following treatment with barbiturates and benzodiazepines. Corticosteroids appear to modulate severity of withdrawal from CNS depressants. Therefore, it was hypothesized that corticosterone would enhance withdrawal convulsions following acute ethanol, pentobarbital, and diazepam in WSP mice. Corticosterone (20 mg/kg) administered following each of these drugs significantly increased severity of handling-induced convulsions during withdrawal. Corticosterone did not affect pre-withdrawal convulsion scores or handling-induced convulsions of drug-naive mice. These results suggest that withdrawal convulsions following acute ethanol, pentobarbital, and diazepam are sensitive to modulation by corticosterone and they support the hypothesis that stress may increase drug withdrawal severity.

Original languageEnglish (US)
Pages (from-to)278-284
Number of pages7
JournalPsychopharmacology
Volume115
Issue number1-2
DOIs
StatePublished - Jun 1994

Fingerprint

Pentobarbital
Diazepam
Corticosterone
Seizures
Ethanol
Central Nervous System Depressants
Pharmaceutical Preparations
Barbiturates
Benzodiazepines
Adrenal Cortex Hormones

Keywords

  • Corticosterone
  • Diazepam
  • Ethanol
  • Mice
  • Pentobarbital
  • Substance withdrawal syndrome

ASJC Scopus subject areas

  • Pharmacology

Cite this

Corticosterone increases severity of acute withdrawal from ethanol, pentobarbital, and diazepam in mice. / Roberts, A. J.; Crabbe, John Jr; Keith, L. D.

In: Psychopharmacology, Vol. 115, No. 1-2, 06.1994, p. 278-284.

Research output: Contribution to journalArticle

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