TY - JOUR
T1 - Cortical elasticity in aging rats with and without growth hormone treatments
AU - Kohles, S. S.
AU - Cartee, G. D.
AU - Vanderby, R.
N1 - Funding Information:
’l‘he authors acknowledge the technical assistance of Hyeonki Choi, Mary Checovich, Laura Nye, Blair Rhode, James Bowers, Arthur Vailas, and Daniel Marti-nez. The experimental groups were provided via funding from the American Federation for Aging Research and National Institute of Aging (AG-10026). Recombinant hGH was provided by Genentech, Inc., San Francisco, CA, US,4.
PY - 1996
Y1 - 1996
N2 - This study quantifies the orthotropic elastic changes in cortical bone due to aging as well as determines any elastic changes after acute treatments of growth hormone (GH). Three groups of twenty rats represented three age groups of young adult (9 months), middle age (20 months), and old (31 months) rats. The normalized, orthotropic elastic properties of Young's moduli (Eii), shear moduli (Gij), and Poisson's ratios ( vij) were calculated and used to compare the groups (where i and j = 1, 2, or 3 reference the radial, circumferential, and longitudinal axes, respectively. Results from a ten day treatment with GH produced no global statistical change in elastic properties (p > 0.05). However, GH did minimize the age related differences that were measured for E22, E33, and v32 between the 9 and 31 month old groups essentially returning old bone to its youthful elastic state.
AB - This study quantifies the orthotropic elastic changes in cortical bone due to aging as well as determines any elastic changes after acute treatments of growth hormone (GH). Three groups of twenty rats represented three age groups of young adult (9 months), middle age (20 months), and old (31 months) rats. The normalized, orthotropic elastic properties of Young's moduli (Eii), shear moduli (Gij), and Poisson's ratios ( vij) were calculated and used to compare the groups (where i and j = 1, 2, or 3 reference the radial, circumferential, and longitudinal axes, respectively. Results from a ten day treatment with GH produced no global statistical change in elastic properties (p > 0.05). However, GH did minimize the age related differences that were measured for E22, E33, and v32 between the 9 and 31 month old groups essentially returning old bone to its youthful elastic state.
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U2 - 10.3109/03091909609008396
DO - 10.3109/03091909609008396
M3 - Article
C2 - 8934407
AN - SCOPUS:0030199047
SN - 0309-1902
VL - 20
SP - 157
EP - 163
JO - Journal of Medical Engineering and Technology
JF - Journal of Medical Engineering and Technology
IS - 4-5
ER -