This study quantifies the orthotropic elastic changes in cortical bone due to aging as well as determines any elastic changes after acute treatments of growth hormone (GH). Three groups of twenty rats represented three age groups of young adult (9 months), middle age (20 months), and old (31 months) rats. The normalized, orthotropic elastic properties of Young's moduli (Eii), shear moduli (Gij), and Poisson's ratios ( vij) were calculated and used to compare the groups (where i and j = 1, 2, or 3 reference the radial, circumferential, and longitudinal axes, respectively. Results from a ten day treatment with GH produced no global statistical change in elastic properties (p > 0.05). However, GH did minimize the age related differences that were measured for E22, E33, and v32 between the 9 and 31 month old groups essentially returning old bone to its youthful elastic state.
ASJC Scopus subject areas
- Biomedical Engineering