Correlative histochemical and histological studies on thirty radical prostatectomy specimens

D. Kirchheim, Nelson (Sam) Niles, E. Frankus, C. V. Hodges

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Whole transverse cryostat sections were made on 30 radical prostatectomy specimens which contained primary prostatic cancer. One was a clinical stage A lesion. The others were diagnosed clinically as stage B but 6 were pathologically stage C. All prostatic cancers originated in the outer prostate close to the true capsule. Capsular and perineural space invasion was seen in all 30. Prostatic cancer produces acid phosphatase but usually in reduced amounts proportional to the degree of the dedifferentiation. This allowed easy identification of prostatic cancer cells in the capsule and periprostatic tissues and distinguished primary from secondary prostatic cancers. The vast majority of prostatic cancers, including well‐differentiated lesions, demonstrated no amino‐peptidase activity; this feature may become an adjunct in their microscopic diagnosis. The potential of histochemical techniques in demonstrating biochemical lesions in cancer cells even in the absence of morphological changes is discussed.

Original languageEnglish (US)
Pages (from-to)1683-1696
Number of pages14
JournalCancer
Volume19
Issue number11
DOIs
StatePublished - 1966

Fingerprint

Prostatectomy
Prostatic Neoplasms
Capsules
Aminopeptidases
Acid Phosphatase
Prostate
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Correlative histochemical and histological studies on thirty radical prostatectomy specimens. / Kirchheim, D.; Niles, Nelson (Sam); Frankus, E.; Hodges, C. V.

In: Cancer, Vol. 19, No. 11, 1966, p. 1683-1696.

Research output: Contribution to journalArticle

Kirchheim, D. ; Niles, Nelson (Sam) ; Frankus, E. ; Hodges, C. V. / Correlative histochemical and histological studies on thirty radical prostatectomy specimens. In: Cancer. 1966 ; Vol. 19, No. 11. pp. 1683-1696.
@article{5688bd20e2234531b162f5a8cb048da4,
title = "Correlative histochemical and histological studies on thirty radical prostatectomy specimens",
abstract = "Whole transverse cryostat sections were made on 30 radical prostatectomy specimens which contained primary prostatic cancer. One was a clinical stage A lesion. The others were diagnosed clinically as stage B but 6 were pathologically stage C. All prostatic cancers originated in the outer prostate close to the true capsule. Capsular and perineural space invasion was seen in all 30. Prostatic cancer produces acid phosphatase but usually in reduced amounts proportional to the degree of the dedifferentiation. This allowed easy identification of prostatic cancer cells in the capsule and periprostatic tissues and distinguished primary from secondary prostatic cancers. The vast majority of prostatic cancers, including well‐differentiated lesions, demonstrated no amino‐peptidase activity; this feature may become an adjunct in their microscopic diagnosis. The potential of histochemical techniques in demonstrating biochemical lesions in cancer cells even in the absence of morphological changes is discussed.",
author = "D. Kirchheim and Niles, {Nelson (Sam)} and E. Frankus and Hodges, {C. V.}",
year = "1966",
doi = "10.1002/1097-0142(196611)19:11<1683::AID-CNCR2820191137>3.0.CO;2-I",
language = "English (US)",
volume = "19",
pages = "1683--1696",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "11",

}

TY - JOUR

T1 - Correlative histochemical and histological studies on thirty radical prostatectomy specimens

AU - Kirchheim, D.

AU - Niles, Nelson (Sam)

AU - Frankus, E.

AU - Hodges, C. V.

PY - 1966

Y1 - 1966

N2 - Whole transverse cryostat sections were made on 30 radical prostatectomy specimens which contained primary prostatic cancer. One was a clinical stage A lesion. The others were diagnosed clinically as stage B but 6 were pathologically stage C. All prostatic cancers originated in the outer prostate close to the true capsule. Capsular and perineural space invasion was seen in all 30. Prostatic cancer produces acid phosphatase but usually in reduced amounts proportional to the degree of the dedifferentiation. This allowed easy identification of prostatic cancer cells in the capsule and periprostatic tissues and distinguished primary from secondary prostatic cancers. The vast majority of prostatic cancers, including well‐differentiated lesions, demonstrated no amino‐peptidase activity; this feature may become an adjunct in their microscopic diagnosis. The potential of histochemical techniques in demonstrating biochemical lesions in cancer cells even in the absence of morphological changes is discussed.

AB - Whole transverse cryostat sections were made on 30 radical prostatectomy specimens which contained primary prostatic cancer. One was a clinical stage A lesion. The others were diagnosed clinically as stage B but 6 were pathologically stage C. All prostatic cancers originated in the outer prostate close to the true capsule. Capsular and perineural space invasion was seen in all 30. Prostatic cancer produces acid phosphatase but usually in reduced amounts proportional to the degree of the dedifferentiation. This allowed easy identification of prostatic cancer cells in the capsule and periprostatic tissues and distinguished primary from secondary prostatic cancers. The vast majority of prostatic cancers, including well‐differentiated lesions, demonstrated no amino‐peptidase activity; this feature may become an adjunct in their microscopic diagnosis. The potential of histochemical techniques in demonstrating biochemical lesions in cancer cells even in the absence of morphological changes is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0013974759&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0013974759&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(196611)19:11<1683::AID-CNCR2820191137>3.0.CO;2-I

DO - 10.1002/1097-0142(196611)19:11<1683::AID-CNCR2820191137>3.0.CO;2-I

M3 - Article

VL - 19

SP - 1683

EP - 1696

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 11

ER -