Objective: To assess whether change in endoscopy score correlates with change in health-related quality of life (HRQOL) following endoscopic sinus surgery for chronic rhinosinusitis. Design: Prospective open cohort. Setting: Tertiary rhinology clinic. Patients: One hundred two adult patients with and without nasal polyposis who elected to undergo endoscopic sinus surgery and were followed up for 12±2 months postoperatively. Intervention: Patient characteristics and Lund-Mackay computed tomography scores were recorded preoperatively. Lund-Kennedy endoscopy scores and 2 HRQOL surveys, the Rhinosinusitis Disability Index and Chronic Sinusitis Survey, were examined before and after surgery. Main Outcome Measures: Postoperative changes in endoscopy score and HRQOL were examined using bivariate and multivariate analyses. Results: Statistically significant improvements were found in endoscopy score (P<.001) and for all total and subscale HRQOL measures (P<.001). After controlling for baseline status and comorbid factors, improvement in endoscopy score significantly correlated with 12-month improvement on the total Rhinosinusitis Disability Index (P=.01), the physical (P=.01) and functional (P=.02) subscales of the Rhinosinusitis Disability Index, and the symptom subscale of the Chronic Sinusitis Survey (P=.003) but could explain only 25.5% to 36.6% of the linear variation for these HRQOL improvements. Conclusions: For most patients, endoscopy scores and disease-specific HRQOL significantly improve after endoscopic sinus surgery. Changes in endoscopy scores explain a portion of the improvement in HRQOL. For patients with chronic rhinosinusitis, improvements in disease-specific HRQOL outcomes are complex, multi-dimensional constructs that cannot be entirely explained by surgical changes measured by endoscopic examination. Trial Registration: clinicaltrials.gov Identifier: NCT00799097.
|Original language||English (US)|
|Number of pages||7|
|Journal||Archives of Otolaryngology - Head and Neck Surgery|
|State||Published - Apr 1 2010|
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