Correlation between the high-frequency content of the QRS on murine surface electrocardiogram and the sympathetic nerves density in left ventricle after myocardial infarction: Experimental study

Golriz Sedaghat, Ryan T. Gardner, Muammar M. Kabir, Elyar Ghafoori, Beth A. Habecker, Larisa G. Tereshchenko

Research output: Research - peer-reviewArticle

Abstract

Denervated post-infarct scar is arrhythmogenic. Our aim was to compare QRS frequency content in denervated and innervated left ventricular (LV) scar. In-vivo single lead ECG telemetry device was implanted in 17 heterozygous PTPσ (HET) and 7 lacking PTPσ (KO) transgenic mice. Myocardial infarction (MI) with reperfusion and sham surgery was performed. HET mice developed a denervated scar, whereas KO mice developed innervated scar. The power spectral density was used to assess the QRS frequency content. Denervated as compared to innervated post-MI scar was characterized by the higher relative contribution of 300-500. Hz (14. ±. 1 vs. 9. ±. 1%; P = 0.001) but reduced relative contribution of 200-300. Hz (86. ±. 1 vs. 91. ±. 1%; P = 0.001). Norepinephrine concentration in peri-infarct zone correlated with both 1-200. Hz (r = 0.75; P = 0.03) and 200-500. Hz QRS power (r = 0.73; P = 0.04). Sympathetic fiber density within the infarct correlated with 200-300/200-500. Hz QRS power ratio (r = 0.56; P = 0.005). Intracellular sigma peptide injections in post-MI HET mice restored the QRS power.

LanguageEnglish (US)
JournalJournal of Electrocardiology
DOIs
StateAccepted/In press - 2017

Fingerprint

Heart Ventricles
Cicatrix
Electrocardiography
Myocardial Infarction
Adrenergic Fibers
Telemetry
Transgenic Mice
Reperfusion
Norepinephrine
Equipment and Supplies
Peptides
Injections

Keywords

  • Electrocardiogram
  • Post-myocardial infarction scar
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{8e9c16b9f31f44ac842a85d8e0a85794,
title = "Correlation between the high-frequency content of the QRS on murine surface electrocardiogram and the sympathetic nerves density in left ventricle after myocardial infarction: Experimental study",
abstract = "Denervated post-infarct scar is arrhythmogenic. Our aim was to compare QRS frequency content in denervated and innervated left ventricular (LV) scar. In-vivo single lead ECG telemetry device was implanted in 17 heterozygous PTPσ (HET) and 7 lacking PTPσ (KO) transgenic mice. Myocardial infarction (MI) with reperfusion and sham surgery was performed. HET mice developed a denervated scar, whereas KO mice developed innervated scar. The power spectral density was used to assess the QRS frequency content. Denervated as compared to innervated post-MI scar was characterized by the higher relative contribution of 300-500. Hz (14. ±. 1 vs. 9. ±. 1%; P = 0.001) but reduced relative contribution of 200-300. Hz (86. ±. 1 vs. 91. ±. 1%; P = 0.001). Norepinephrine concentration in peri-infarct zone correlated with both 1-200. Hz (r = 0.75; P = 0.03) and 200-500. Hz QRS power (r = 0.73; P = 0.04). Sympathetic fiber density within the infarct correlated with 200-300/200-500. Hz QRS power ratio (r = 0.56; P = 0.005). Intracellular sigma peptide injections in post-MI HET mice restored the QRS power.",
keywords = "Electrocardiogram, Post-myocardial infarction scar, Sympathetic nervous system",
author = "Golriz Sedaghat and Gardner, {Ryan T.} and Kabir, {Muammar M.} and Elyar Ghafoori and Habecker, {Beth A.} and Tereshchenko, {Larisa G.}",
year = "2017",
doi = "10.1016/j.jelectrocard.2017.01.014",
journal = "Journal of Electrocardiology",
issn = "0022-0736",
publisher = "Churchill Livingstone",

}

TY - JOUR

T1 - Correlation between the high-frequency content of the QRS on murine surface electrocardiogram and the sympathetic nerves density in left ventricle after myocardial infarction

T2 - Journal of Electrocardiology

AU - Sedaghat,Golriz

AU - Gardner,Ryan T.

AU - Kabir,Muammar M.

AU - Ghafoori,Elyar

AU - Habecker,Beth A.

AU - Tereshchenko,Larisa G.

PY - 2017

Y1 - 2017

N2 - Denervated post-infarct scar is arrhythmogenic. Our aim was to compare QRS frequency content in denervated and innervated left ventricular (LV) scar. In-vivo single lead ECG telemetry device was implanted in 17 heterozygous PTPσ (HET) and 7 lacking PTPσ (KO) transgenic mice. Myocardial infarction (MI) with reperfusion and sham surgery was performed. HET mice developed a denervated scar, whereas KO mice developed innervated scar. The power spectral density was used to assess the QRS frequency content. Denervated as compared to innervated post-MI scar was characterized by the higher relative contribution of 300-500. Hz (14. ±. 1 vs. 9. ±. 1%; P = 0.001) but reduced relative contribution of 200-300. Hz (86. ±. 1 vs. 91. ±. 1%; P = 0.001). Norepinephrine concentration in peri-infarct zone correlated with both 1-200. Hz (r = 0.75; P = 0.03) and 200-500. Hz QRS power (r = 0.73; P = 0.04). Sympathetic fiber density within the infarct correlated with 200-300/200-500. Hz QRS power ratio (r = 0.56; P = 0.005). Intracellular sigma peptide injections in post-MI HET mice restored the QRS power.

AB - Denervated post-infarct scar is arrhythmogenic. Our aim was to compare QRS frequency content in denervated and innervated left ventricular (LV) scar. In-vivo single lead ECG telemetry device was implanted in 17 heterozygous PTPσ (HET) and 7 lacking PTPσ (KO) transgenic mice. Myocardial infarction (MI) with reperfusion and sham surgery was performed. HET mice developed a denervated scar, whereas KO mice developed innervated scar. The power spectral density was used to assess the QRS frequency content. Denervated as compared to innervated post-MI scar was characterized by the higher relative contribution of 300-500. Hz (14. ±. 1 vs. 9. ±. 1%; P = 0.001) but reduced relative contribution of 200-300. Hz (86. ±. 1 vs. 91. ±. 1%; P = 0.001). Norepinephrine concentration in peri-infarct zone correlated with both 1-200. Hz (r = 0.75; P = 0.03) and 200-500. Hz QRS power (r = 0.73; P = 0.04). Sympathetic fiber density within the infarct correlated with 200-300/200-500. Hz QRS power ratio (r = 0.56; P = 0.005). Intracellular sigma peptide injections in post-MI HET mice restored the QRS power.

KW - Electrocardiogram

KW - Post-myocardial infarction scar

KW - Sympathetic nervous system

UR - http://www.scopus.com/inward/record.url?scp=85012898264&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012898264&partnerID=8YFLogxK

U2 - 10.1016/j.jelectrocard.2017.01.014

DO - 10.1016/j.jelectrocard.2017.01.014

M3 - Article

JO - Journal of Electrocardiology

JF - Journal of Electrocardiology

SN - 0022-0736

ER -