Correlating thrombus constituents of surface-modified vascular graft materials to luminal volume using microct to better quantify clinical functionality

Deirdre E.J. Anderson, Avi Gupta, Monica Hinds

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An important consideration in the design of cardiovascular biomaterials is the prevention of thrombus formation when exposed to blood. Thrombus formation is initiated by the activation of coagulation factor XII (FXII) to FXIIa leading to thrombin formation and activation of platelets. Thrombi formed under blood flow are complex structures of blood coagulation factors, cellular components, and fibrin fibers. In the case of vascular grafts, thrombi invade the graft lumen and reduce blood flow. For many decades, thrombosis has been assessed using a chronic arteriovenous shunt implant in a non-human primate model. It has been used to study novel and clinically approved medications, novel and clinically-used vascular devices, and combinations of medications and devices. With this established technique data is collected to quantify platelet accumulation over time as well as endpoint fibrin accumulation. While this provides a reliable and quantifiable metric for assessing thrombus formation, it does little to elucidate the physical characteristics of the thrombus including size and feature morphology. This information would be particularly useful when evaluating new biomaterials designed to inhibit thrombus formation. To better assess thrombus structure, we have developed a technique using microCT to quantify luminal volume of a variety of vascular graft biomaterials. Additionally, we correlated luminal volume to platelet and fibrin quantities to allow translation of this work to broader applications.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Correlating thrombus constituents of surface-modified vascular graft materials to luminal volume using microct to better quantify clinical functionality'. Together they form a unique fingerprint.

  • Cite this

    Anderson, D. E. J., Gupta, A., & Hinds, M. (2019). Correlating thrombus constituents of surface-modified vascular graft materials to luminal volume using microct to better quantify clinical functionality. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.