Correlates of T 50 and relationships with bone mineral density in community-living older men

the osteoporotic fractures in men (MrOS) study

A. L. Bullen, C. A.M. Anderson, E. R. Hooker, D. M. Kado, Eric Orwoll, A. Pasch, J. H. Ix

Research output: Contribution to journalArticle

Abstract

Purpose: T 50 is a novel serum-based marker that assesses the propensity of calcification in serum. Shorter T 50 indicates greater propensity to calcify and it has been associated to cardiovascular disease (CVD) and mortality among patients with kidney disease. In the general population, neither the correlates of T 50 nor the relationships of T 50 with bone mineral density (BMD) are known. Methods: We performed a nested cross-sectional study selecting 150 individuals at random among participants from the Osteoporotic Fractures in Men (MrOS) Study, a study of community-living older men. We categorized individuals into tertiles of T 50 and compared demographics and disease indicators across tertiles. We utilized linear regression to evaluate the cross-sectional association between T 50 and hip and spine BMD in multivariable models. Results: Older age was associated with shorter T 50 . Kidney function tended to be lower in those with shorter T 50 and the prevalence of CVD and peripheral arterial disease in those with shorter T 50 , albeit these findings did not achieve statistical significance. We found no statistically significant associations between T 50 and total hip or total spine BMD in either unadjusted or multivariable adjusted models. Conclusions: T 50 , a novel indicator of serum calcification propensity, is not associated with BMD in community-living older men. Future larger studies should determine if T 50 may give insights to CVD in the general population above and beyond traditional risk factors.

Original languageEnglish (US)
JournalOsteoporosis International
DOIs
StatePublished - Jan 1 2019

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Osteoporotic Fractures
Bone Density
Cardiovascular Diseases
Spine
Pelvic Bones
Peripheral Arterial Disease
Kidney Diseases
Serum
Population
Hip
Linear Models
Cross-Sectional Studies
Biomarkers
Demography
Kidney
Mortality

Keywords

  • Bone mineral density
  • Calcification propensity score

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Correlates of T 50 and relationships with bone mineral density in community-living older men : the osteoporotic fractures in men (MrOS) study. / Bullen, A. L.; Anderson, C. A.M.; Hooker, E. R.; Kado, D. M.; Orwoll, Eric; Pasch, A.; Ix, J. H.

In: Osteoporosis International, 01.01.2019.

Research output: Contribution to journalArticle

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abstract = "Purpose: T 50 is a novel serum-based marker that assesses the propensity of calcification in serum. Shorter T 50 indicates greater propensity to calcify and it has been associated to cardiovascular disease (CVD) and mortality among patients with kidney disease. In the general population, neither the correlates of T 50 nor the relationships of T 50 with bone mineral density (BMD) are known. Methods: We performed a nested cross-sectional study selecting 150 individuals at random among participants from the Osteoporotic Fractures in Men (MrOS) Study, a study of community-living older men. We categorized individuals into tertiles of T 50 and compared demographics and disease indicators across tertiles. We utilized linear regression to evaluate the cross-sectional association between T 50 and hip and spine BMD in multivariable models. Results: Older age was associated with shorter T 50 . Kidney function tended to be lower in those with shorter T 50 and the prevalence of CVD and peripheral arterial disease in those with shorter T 50 , albeit these findings did not achieve statistical significance. We found no statistically significant associations between T 50 and total hip or total spine BMD in either unadjusted or multivariable adjusted models. Conclusions: T 50 , a novel indicator of serum calcification propensity, is not associated with BMD in community-living older men. Future larger studies should determine if T 50 may give insights to CVD in the general population above and beyond traditional risk factors.",
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AU - Hooker, E. R.

AU - Kado, D. M.

AU - Orwoll, Eric

AU - Pasch, A.

AU - Ix, J. H.

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