Correlates of T 50 and relationships with bone mineral density in community-living older men: the osteoporotic fractures in men (MrOS) study

A. L. Bullen, C. A.M. Anderson, E. R. Hooker, D. M. Kado, Eric Orwoll, A. Pasch, J. H. Ix

Research output: Contribution to journalArticle

Abstract

Purpose: T 50 is a novel serum-based marker that assesses the propensity of calcification in serum. Shorter T 50 indicates greater propensity to calcify and it has been associated to cardiovascular disease (CVD) and mortality among patients with kidney disease. In the general population, neither the correlates of T 50 nor the relationships of T 50 with bone mineral density (BMD) are known. Methods: We performed a nested cross-sectional study selecting 150 individuals at random among participants from the Osteoporotic Fractures in Men (MrOS) Study, a study of community-living older men. We categorized individuals into tertiles of T 50 and compared demographics and disease indicators across tertiles. We utilized linear regression to evaluate the cross-sectional association between T 50 and hip and spine BMD in multivariable models. Results: Older age was associated with shorter T 50 . Kidney function tended to be lower in those with shorter T 50 and the prevalence of CVD and peripheral arterial disease in those with shorter T 50 , albeit these findings did not achieve statistical significance. We found no statistically significant associations between T 50 and total hip or total spine BMD in either unadjusted or multivariable adjusted models. Conclusions: T 50 , a novel indicator of serum calcification propensity, is not associated with BMD in community-living older men. Future larger studies should determine if T 50 may give insights to CVD in the general population above and beyond traditional risk factors.

Original languageEnglish (US)
JournalOsteoporosis International
DOIs
StatePublished - Jan 1 2019

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Osteoporotic Fractures
Bone Density
Cardiovascular Diseases
Spine
Pelvic Bones
Peripheral Arterial Disease
Kidney Diseases
Serum
Population
Hip
Linear Models
Cross-Sectional Studies
Biomarkers
Demography
Kidney
Mortality

Keywords

  • Bone mineral density
  • Calcification propensity score

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Correlates of T 50 and relationships with bone mineral density in community-living older men : the osteoporotic fractures in men (MrOS) study. / Bullen, A. L.; Anderson, C. A.M.; Hooker, E. R.; Kado, D. M.; Orwoll, Eric; Pasch, A.; Ix, J. H.

In: Osteoporosis International, 01.01.2019.

Research output: Contribution to journalArticle

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AU - Hooker, E. R.

AU - Kado, D. M.

AU - Orwoll, Eric

AU - Pasch, A.

AU - Ix, J. H.

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