Correlated gene expression and anatomical communication support synchronized brain activity in the mouse functional connectome

Brian D. Mills, David S. Grayson, Anandakumar Shunmugavel, Oscar Miranda-Dominguez, Eric Feczko, Eric Earl, Kim A. Neve, Damien A. Fair

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Cognition and behavior depend on synchronized intrinsic brain activity that is organized into functional networks across the brain. Research has investigated how anatomical connectivity both shapes and is shaped by these networks, but not how anatomical connectivity interacts with intra-areal molecular properties to drive functional connectivity. Here, we present a novel linear model to explain functional connectivity by integrating systematically obtained measurements of axonal connectivity, gene expression, and resting-state functional connectivity MRI in the mouse brain. The model suggests that functional connectivity arises from both anatomical links and inter-areal similarities in gene expression. By estimating these effects, we identify anatomical modules in which correlated gene expression and anatomical connectivity support functional connectivity. Along with providing evidence that not all genes equally contribute to functional connectivity, this research establishes new insights regarding the biological underpinnings of coordinated brain activity measured by BOLD fMRI.

Original languageEnglish (US)
Pages (from-to)5774-5787
Number of pages14
JournalJournal of Neuroscience
Volume38
Issue number25
DOIs
StatePublished - Jun 20 2018

Keywords

  • Anatomical connectivity
  • Connectomics
  • Gene expression
  • Resting state functional connectivity MRI

ASJC Scopus subject areas

  • Neuroscience(all)

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