Correction: A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration (PLoS ONE (2011) 6:10 (e25598) DOI: 10.1371/journal.pone.0025598)

Theru A. Sivakumaran, Robert P. Igo, Jeffrey M. Kidd, Andy Itsara, Laura J. Kopplin, Wei Chen, Stephanie A. Hagstrom, Neal S. Peachey, Peter J. Francis, Michael Klein, Emily Y. Chew, Vedam L. Ramprasad, Wan Ting Tay, Paul Mitchell, Mark Seielstad, Dwight E. Stambolian, Albert O. Edwards, Kristine E. Lee, Dmitry V. Leontiev, Gyungah JunYang Wang, Liping Tian, Feiyou Qiu, Alice K. Henning, Thomas LaFramboise, Parveen Sen, Manoharan Aarthi, Ronnie George, Rajiv Raman, Manmath Kumar Das, Lingam Vijaya, Govindasamy Kumaramanickavel, Tien Y. Wong, Anand Swaroop, Goncalo R. Abecasis, Ronald Klein, Barbara E.K. Klein, Deborah A. Nickerson, Evan E. Eichler, Sudha K. Iyengar

Research output: Contribution to journalComment/debate

Abstract

The authors have stated that the coordinates of two deletions of the CFHR gene cluster on chromosome 1 represent the outer boundaries of the deletion interval based on patterns of sequence identity and included both copies of the duplicated sequence where breakpoint definition is difficult. For CNP147, this interval of 86.302kbp (chr1: 194988828-195075129) includes 1617 bp of 100% identical sequence located at the 5' and 3' breakpoints. Since the deletion allele retains a single copy of this sequence by virtue of non-allelic homologous recombination, the CNP147 deletion event in fact removes 84.685 kbp, a size consistent with the findings of Hughes et al. (Hughes et al Nature Genetics, volume 38, 1173-1177, 2006). Similarly, the reported boundaries for CNP148 with an interval of 121.959 kbp (chr1: 195049336- 195171294) include a 59 bp segment of identical sequence at each breakpoint and therefore results in a loss of 121.9 kbp. The CNP148 breakpoints are further embedded within an extended segment of high sequence identity (> 1kbp and 99% identity). The authors would like to make multiple corrections.

Original languageEnglish (US)
Article number0209943
JournalPLoS One
Volume13
Issue number12
DOIs
StatePublished - Dec 1 2018

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Chromosomes, Human, Pair 1
Homologous Recombination
homologous recombination
Macular Degeneration
Chromosomes
Multigene Family
multigene family
Genes
Alleles
alleles
chromosomes
macular degeneration
Genetics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Correction : A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration (PLoS ONE (2011) 6:10 (e25598) DOI: 10.1371/journal.pone.0025598). / Sivakumaran, Theru A.; Igo, Robert P.; Kidd, Jeffrey M.; Itsara, Andy; Kopplin, Laura J.; Chen, Wei; Hagstrom, Stephanie A.; Peachey, Neal S.; Francis, Peter J.; Klein, Michael; Chew, Emily Y.; Ramprasad, Vedam L.; Tay, Wan Ting; Mitchell, Paul; Seielstad, Mark; Stambolian, Dwight E.; Edwards, Albert O.; Lee, Kristine E.; Leontiev, Dmitry V.; Jun, Gyungah; Wang, Yang; Tian, Liping; Qiu, Feiyou; Henning, Alice K.; LaFramboise, Thomas; Sen, Parveen; Aarthi, Manoharan; George, Ronnie; Raman, Rajiv; Das, Manmath Kumar; Vijaya, Lingam; Kumaramanickavel, Govindasamy; Wong, Tien Y.; Swaroop, Anand; Abecasis, Goncalo R.; Klein, Ronald; Klein, Barbara E.K.; Nickerson, Deborah A.; Eichler, Evan E.; Iyengar, Sudha K.

In: PLoS One, Vol. 13, No. 12, 0209943, 01.12.2018.

Research output: Contribution to journalComment/debate

Sivakumaran, TA, Igo, RP, Kidd, JM, Itsara, A, Kopplin, LJ, Chen, W, Hagstrom, SA, Peachey, NS, Francis, PJ, Klein, M, Chew, EY, Ramprasad, VL, Tay, WT, Mitchell, P, Seielstad, M, Stambolian, DE, Edwards, AO, Lee, KE, Leontiev, DV, Jun, G, Wang, Y, Tian, L, Qiu, F, Henning, AK, LaFramboise, T, Sen, P, Aarthi, M, George, R, Raman, R, Das, MK, Vijaya, L, Kumaramanickavel, G, Wong, TY, Swaroop, A, Abecasis, GR, Klein, R, Klein, BEK, Nickerson, DA, Eichler, EE & Iyengar, SK 2018, 'Correction: A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration (PLoS ONE (2011) 6:10 (e25598) DOI: 10.1371/journal.pone.0025598)', PLoS One, vol. 13, no. 12, 0209943. https://doi.org/10.1371/journal.pone.0209943
Sivakumaran, Theru A. ; Igo, Robert P. ; Kidd, Jeffrey M. ; Itsara, Andy ; Kopplin, Laura J. ; Chen, Wei ; Hagstrom, Stephanie A. ; Peachey, Neal S. ; Francis, Peter J. ; Klein, Michael ; Chew, Emily Y. ; Ramprasad, Vedam L. ; Tay, Wan Ting ; Mitchell, Paul ; Seielstad, Mark ; Stambolian, Dwight E. ; Edwards, Albert O. ; Lee, Kristine E. ; Leontiev, Dmitry V. ; Jun, Gyungah ; Wang, Yang ; Tian, Liping ; Qiu, Feiyou ; Henning, Alice K. ; LaFramboise, Thomas ; Sen, Parveen ; Aarthi, Manoharan ; George, Ronnie ; Raman, Rajiv ; Das, Manmath Kumar ; Vijaya, Lingam ; Kumaramanickavel, Govindasamy ; Wong, Tien Y. ; Swaroop, Anand ; Abecasis, Goncalo R. ; Klein, Ronald ; Klein, Barbara E.K. ; Nickerson, Deborah A. ; Eichler, Evan E. ; Iyengar, Sudha K. / Correction : A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration (PLoS ONE (2011) 6:10 (e25598) DOI: 10.1371/journal.pone.0025598). In: PLoS One. 2018 ; Vol. 13, No. 12.
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abstract = "The authors have stated that the coordinates of two deletions of the CFHR gene cluster on chromosome 1 represent the outer boundaries of the deletion interval based on patterns of sequence identity and included both copies of the duplicated sequence where breakpoint definition is difficult. For CNP147, this interval of 86.302kbp (chr1: 194988828-195075129) includes 1617 bp of 100{\%} identical sequence located at the 5' and 3' breakpoints. Since the deletion allele retains a single copy of this sequence by virtue of non-allelic homologous recombination, the CNP147 deletion event in fact removes 84.685 kbp, a size consistent with the findings of Hughes et al. (Hughes et al Nature Genetics, volume 38, 1173-1177, 2006). Similarly, the reported boundaries for CNP148 with an interval of 121.959 kbp (chr1: 195049336- 195171294) include a 59 bp segment of identical sequence at each breakpoint and therefore results in a loss of 121.9 kbp. The CNP148 breakpoints are further embedded within an extended segment of high sequence identity (> 1kbp and 99{\%} identity). The authors would like to make multiple corrections.",
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AU - Sivakumaran, Theru A.

AU - Igo, Robert P.

AU - Kidd, Jeffrey M.

AU - Itsara, Andy

AU - Kopplin, Laura J.

AU - Chen, Wei

AU - Hagstrom, Stephanie A.

AU - Peachey, Neal S.

AU - Francis, Peter J.

AU - Klein, Michael

AU - Chew, Emily Y.

AU - Ramprasad, Vedam L.

AU - Tay, Wan Ting

AU - Mitchell, Paul

AU - Seielstad, Mark

AU - Stambolian, Dwight E.

AU - Edwards, Albert O.

AU - Lee, Kristine E.

AU - Leontiev, Dmitry V.

AU - Jun, Gyungah

AU - Wang, Yang

AU - Tian, Liping

AU - Qiu, Feiyou

AU - Henning, Alice K.

AU - LaFramboise, Thomas

AU - Sen, Parveen

AU - Aarthi, Manoharan

AU - George, Ronnie

AU - Raman, Rajiv

AU - Das, Manmath Kumar

AU - Vijaya, Lingam

AU - Kumaramanickavel, Govindasamy

AU - Wong, Tien Y.

AU - Swaroop, Anand

AU - Abecasis, Goncalo R.

AU - Klein, Ronald

AU - Klein, Barbara E.K.

AU - Nickerson, Deborah A.

AU - Eichler, Evan E.

AU - Iyengar, Sudha K.

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