Corpus luteum rescue in nonhuman primates and women

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    The primate corpus luteum undergoes a process at the end of a nonfertile menstrual cycle termed luteolysis, which involves considerable structural and functional changes that lead to a loss in the ability to produce the steroid hormone progesterone. Because progesterone is critical for events involved in embryo implantation and sustaining pregnancy, the survival and continued function of the corpus luteum are required throughout the fi rst weeks of pregnancy, after which the placenta becomes responsible for the maintenance of gestation. Extension of the functional lifespan of the primate corpus luteum is achieved through the secretion of chorionic gonadotropin (CG) from the conceptus. CG signals through the luteinizing hormone-chorionic gonadotropin receptor (LHCGR) located on luteal cells to override the cellular and molecular events that are responsible for the demise of the corpus luteum during nonfertile cycles. Thus, in this chapter, the source of various CG forms and the regulation of their production, as well as the mechanisms through which LHCGR signaling regulates cellular activities in the primate corpus luteum during early pregnancy are reviewed. Also, current and possible uses of hCG forms for diagnosis and treatment of infertility and pregnancy disorders are considered.

    Original languageEnglish (US)
    Title of host publicationThe Life Cycle of the Corpus Luteum
    PublisherSpringer International Publishing
    Pages183-204
    Number of pages22
    ISBN (Electronic)9783319432380
    ISBN (Print)9783319432366
    DOIs
    StatePublished - Jan 1 2016

    Keywords

    • Chorionic gonadotropin
    • Corpus luteum
    • Luteal rescue
    • Luteinizing hormone-chorionic gonadotropin receptor
    • Luteolysis
    • Maternal recognition of pregnancy
    • Pregnancy
    • Primate
    • Progesterone
    • Relaxin

    ASJC Scopus subject areas

    • Health Professions(all)
    • Medicine(all)
    • Agricultural and Biological Sciences(all)

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  • Cite this

    Stouffer, R., & Hennebold, J. (2016). Corpus luteum rescue in nonhuman primates and women. In The Life Cycle of the Corpus Luteum (pp. 183-204). Springer International Publishing. https://doi.org/10.1007/978-3-319-43238-0_10