Coronary reserve abnormalities in the infarcted myocardium: Assessment of myocardial viability immediately versus late after reflow by contrast echocardiography

Flordeliza S. Villanueva, Gustavo Camarano, Suad Ismail, Norman C. Goodman, Jiri Sklenar, Sanjiv Kaul

    Research output: Contribution to journalArticlepeer-review

    79 Scopus citations

    Abstract

    Background: The aim of this study was to determine whether myocardial contrast echocardiography (MCE) during exogenous vasodilation can accurately delineate infarct size, and hence the extent of myocardial viability, both immediately (15 minutes) and late (3 hours) after reperfusion when postreflow coronary hyperemia is still present. Methods and Results: Twenty-one open- chest anesthetized dogs underwent 3 to 6 hours of coronary occlusion followed by reperfusion. MCE was performed 15 minutes after reflow before and during infusion of 0.2mg · kg-1 · min-1 adenosine IV. In 12 dogs, infarct size was measured at this time. In the remaining 9 dogs, reperfusion was continued for 3 hours, when MCE was repeated before and after an infusion of 0.56 mg · kg-1 min-1 dipyridamole IV and infarct size was measured. In the absence of adenosine, MCE perfusion defect at 15 minutes underestimated infarct sizes at both 15 minutes and 3 hours, whereas in the presence of adenosine, the estimate of infarct size was more accurate. Similarly, in the absence of dipyridamole, although MCE perfusion defect underestimated infarct size (both measured 3 hours after reflow), in the presence of dipyridamole, the estimate of infarct size was more accurate. Conclusions: By unmasking abnormalities in flow reserve within the infarct bed, MCE in conjunction with corollary vasodilators can accurately predict infarct size both 15 minutes and 3 hours after reperfusion. Thus, MCE can be used for assessing the extent of myocardial viability both immediately and late after reperfusion when postreflow coronary hyperemia is still present.

    Original languageEnglish (US)
    Pages (from-to)748-754
    Number of pages7
    JournalCirculation
    Volume94
    Issue number4
    DOIs
    StatePublished - Jan 1 1996

    Keywords

    • echocardiography
    • infarction
    • myocardium
    • vasodilation

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Physiology (medical)

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