Corneal imaging with blue-light optical coherence microscopy

Shanjida Khan, Kai Neuhaus, Omkar Thaware, Shuibin Ni, Myeong Jin Ju, Travis Redd, David Huang, Yifan Jian

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Corneal imaging is important for the diagnostic and therapeutic evaluation of many eye diseases. Optical coherence tomography (OCT) is extensively used in ocular imaging due to its non-invasive and high-resolution volumetric imaging characteristics. Optical coherence microscopy (OCM) is a technical variation of OCT that can image the cornea with cellular resolution. Here, we demonstrate a blue-light OCM as a low-cost and easily reproducible system to visualize corneal cellular structures such as epithelial cells, endothelial cells, keratocytes, and collagen bundles within stromal lamellae. Our blue-light OCM system achieved an axial resolution of 12 µm in tissue over a 1.2 mm imaging depth, and a lateral resolution of 1.6 µm over a field of view of 750 µm × 750 µm.

Original languageEnglish (US)
Pages (from-to)5004-5014
Number of pages11
JournalBiomedical Optics Express
Volume13
Issue number9
DOIs
StatePublished - Sep 1 2022

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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