Corneal epithelial thickness mapping by fourier-domain optical coherence tomography in normal and keratoconic eyes

Yan Li, Ou Tan, Robert Brass, Jack L. Weiss, David Huang

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

Objective: To map the corneal epithelial thickness with Fourier-domain optical coherence tomography (OCT) and to develop epithelial thickness-based variables for keratoconus detection. Design: Cross-sectional observational study. Participants: One hundred forty-five eyes from 76 normal subjects and 35 keratoconic eyes from 22 patients. Methods: A 26 000-Hz Fourier-domain OCT system with 5-μm axial resolution was used. The cornea was imaged with a Pachymetry+Cpwr scan pattern (6-mm scan diameter, 8 radials, 1024 axial-scans each, repeated 5 times) centered on the pupil. Three scans were obtained at a single visit in a prospective study. A computer algorithm was developed to map the corneal epithelial thickness automatically. Zonal epithelial thicknesses and 5 diagnostic variables, including minimum, superior-inferior (S-I), minimum-maximum (MIN-MAX), map standard deviation (MSD), and pattern standard deviation (PSD), were calculated. Repeatability of the measurements was assessed by the pooled standard deviation. The area under the receiver operating characteristic curve (AUC) was used to evaluate diagnostic accuracy. Main Outcome Measures: Descriptive statistics, repeatability, and AUC of the zonal epithelial thickness and diagnostic variables. Results: The central, superior, and inferior epithelial thickness averages were 52.3±3.6 μm, 49.6±3.5 μm, and 51.2±3.4 μm in normal eyes and 51.9±5.3 μm, 51.2±4.2 μm, and 49.1±4.3 μm in keratoconic eyes. Compared with normal eyes, keratoconic eyes had significantly lower inferior (P = 0.03) and minimum (P

Original languageEnglish (US)
Pages (from-to)2425-2433
Number of pages9
JournalOphthalmology
Volume119
Issue number12
DOIs
StatePublished - Dec 2012

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Optical Coherence Tomography
Area Under Curve
faropenem medoxomil
Keratoconus
Pupil
ROC Curve
Cornea
Observational Studies
Cross-Sectional Studies
Outcome Assessment (Health Care)
Prospective Studies

ASJC Scopus subject areas

  • Ophthalmology

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Corneal epithelial thickness mapping by fourier-domain optical coherence tomography in normal and keratoconic eyes. / Li, Yan; Tan, Ou; Brass, Robert; Weiss, Jack L.; Huang, David.

In: Ophthalmology, Vol. 119, No. 12, 12.2012, p. 2425-2433.

Research output: Contribution to journalArticle

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