Corepressor-dependent silencing of chromosomal regions encoding neuronal genes

Victoria V. Lunyak, Robert Burgess, Gratien G. Prefontaine, Charles Nelson, Sing Hoi Sze, Josh Chenoweth, Phillip Schwartz, Pavel A. Pevzner, Christopher Glass, Gail Mandel, Michael G. Rosenfeld

Research output: Contribution to journalArticle

371 Scopus citations

Abstract

The molecular mechanisms by which central nervous system-specific genes are expressed only in the nervous system and repressed in other tissues remain a central issue in developmental and regulatory biology. Here, we report that the zinc-finger gene-specific repressor element RE-1 silencing transcription factor/neuronal restricted silencing factor (REST/NRSF) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long-term gene silencing using a distinct functional complex. Silencing of neuronal-specific genes requires the recruitment of an associated corepressor, CoREST, that serves as a functional molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval, including transcriptional units that do not themselves contain REST/NRSF response elements.

Original languageEnglish (US)
Pages (from-to)1747-1752
Number of pages6
JournalScience
Volume298
Issue number5599
DOIs
StatePublished - Nov 29 2002

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    Lunyak, V. V., Burgess, R., Prefontaine, G. G., Nelson, C., Sze, S. H., Chenoweth, J., Schwartz, P., Pevzner, P. A., Glass, C., Mandel, G., & Rosenfeld, M. G. (2002). Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science, 298(5599), 1747-1752. https://doi.org/10.1126/science.1076469