Corepressor-dependent silencing of chromosomal regions encoding neuronal genes

Victoria V. Lunyak, Robert Burgess, Gratien G. Prefontaine, Charles Nelson, Sing Hoi Sze, Josh Chenoweth, Phillip Schwartz, Pavel A. Pevzner, Christopher Glass, Gail Mandel, Michael G. Rosenfeld

Research output: Contribution to journalArticle

363 Citations (Scopus)

Abstract

The molecular mechanisms by which central nervous system-specific genes are expressed only in the nervous system and repressed in other tissues remain a central issue in developmental and regulatory biology. Here, we report that the zinc-finger gene-specific repressor element RE-1 silencing transcription factor/neuronal restricted silencing factor (REST/NRSF) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long-term gene silencing using a distinct functional complex. Silencing of neuronal-specific genes requires the recruitment of an associated corepressor, CoREST, that serves as a functional molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval, including transcriptional units that do not themselves contain REST/NRSF response elements.

Original languageEnglish (US)
Pages (from-to)1747-1752
Number of pages6
JournalScience
Volume298
Issue number5599
DOIs
StatePublished - Nov 29 2002
Externally publishedYes

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Co-Repressor Proteins
Transcription Factors
Genes
Developmental Biology
Histone Deacetylases
Zinc Fingers
Response Elements
Gene Silencing
Nervous System
Central Nervous System

ASJC Scopus subject areas

  • General

Cite this

Lunyak, V. V., Burgess, R., Prefontaine, G. G., Nelson, C., Sze, S. H., Chenoweth, J., ... Rosenfeld, M. G. (2002). Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science, 298(5599), 1747-1752. https://doi.org/10.1126/science.1076469

Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. / Lunyak, Victoria V.; Burgess, Robert; Prefontaine, Gratien G.; Nelson, Charles; Sze, Sing Hoi; Chenoweth, Josh; Schwartz, Phillip; Pevzner, Pavel A.; Glass, Christopher; Mandel, Gail; Rosenfeld, Michael G.

In: Science, Vol. 298, No. 5599, 29.11.2002, p. 1747-1752.

Research output: Contribution to journalArticle

Lunyak, VV, Burgess, R, Prefontaine, GG, Nelson, C, Sze, SH, Chenoweth, J, Schwartz, P, Pevzner, PA, Glass, C, Mandel, G & Rosenfeld, MG 2002, 'Corepressor-dependent silencing of chromosomal regions encoding neuronal genes', Science, vol. 298, no. 5599, pp. 1747-1752. https://doi.org/10.1126/science.1076469
Lunyak VV, Burgess R, Prefontaine GG, Nelson C, Sze SH, Chenoweth J et al. Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. Science. 2002 Nov 29;298(5599):1747-1752. https://doi.org/10.1126/science.1076469
Lunyak, Victoria V. ; Burgess, Robert ; Prefontaine, Gratien G. ; Nelson, Charles ; Sze, Sing Hoi ; Chenoweth, Josh ; Schwartz, Phillip ; Pevzner, Pavel A. ; Glass, Christopher ; Mandel, Gail ; Rosenfeld, Michael G. / Corepressor-dependent silencing of chromosomal regions encoding neuronal genes. In: Science. 2002 ; Vol. 298, No. 5599. pp. 1747-1752.
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