Cord blood leptin is associated with size at birth and predicts infancy weight gain in humans

Ken Kl Ong, Marion L. Ahmed, Andrea Sherriff, Kathryn (Katie) Woods, Angie Watts, Jean Golding, David B. Dunger

Research output: Contribution to journalArticle

200 Scopus citations

Abstract

Recent discoveries of human genetic leptin deficiency have demonstrated its importance in regulating weight gain in early childhood. To investigate whether normal variation in leptin and insulin levels in cord blood could influence infancy growth, we assayed samples from 197 infants from a representative birth cohort, who were measured at birth, 4, 8, 12 and 24 months. Cord leptin levels correlated most closely with weight and ponderal index (kg/m3) at birth, but also with length and head circumference (all p

Original languageEnglish (US)
Pages (from-to)1145-1148
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume84
Issue number3
Publication statusPublished - 1999
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Ong, K. K., Ahmed, M. L., Sherriff, A., Woods, K. K., Watts, A., Golding, J., & Dunger, D. B. (1999). Cord blood leptin is associated with size at birth and predicts infancy weight gain in humans. Journal of Clinical Endocrinology and Metabolism, 84(3), 1145-1148.