TY - JOUR
T1 - COPD and occupational exposures
T2 - A case-control study
AU - Weinmann, Sheila
AU - Vollmer, William M.
AU - Breen, Victor
AU - Heumann, Michael
AU - Hnizdo, Eva
AU - Villnave, Jacqueline
AU - Doney, Brent
AU - Graziani, Monica
AU - McBurnie, Mary Ann
AU - Buist, A. Sonia
PY - 2008/5
Y1 - 2008/5
N2 - OBJECTIVE: Evidence demonstrates that occupational exposures are causally linked with chronic obstructive pulmonary disease (COPD). This case-control study evaluated the association between occupational exposures and prevalent COPD based on lifetime occupational history. METHODS: Cases (n = 388) aged 45 years and older with COPD were compared with controls (n = 356), frequency matched on age, sex, and cigarette smoking history. Odds ratios for exposure to each of eight occupational hazard categories and three composite measures of exposure were computed using logistic regression. RESULTS: Occupational exposures most strongly associated with COPD were diesel exhaust, irritant gases and vapors, mineral dust, and metal dust. The composite measures describing aggregate exposure to gases, vapors, solvents, or sensitizers (GVSS) and aggregate exposure to dust, GVSS, or diesel exhaust were also associated with COPD. In the small group of never-smokers, a similar pattern was evident. CONCLUSION: These population-based findings add to the literature linking occupational exposures to COPD.
AB - OBJECTIVE: Evidence demonstrates that occupational exposures are causally linked with chronic obstructive pulmonary disease (COPD). This case-control study evaluated the association between occupational exposures and prevalent COPD based on lifetime occupational history. METHODS: Cases (n = 388) aged 45 years and older with COPD were compared with controls (n = 356), frequency matched on age, sex, and cigarette smoking history. Odds ratios for exposure to each of eight occupational hazard categories and three composite measures of exposure were computed using logistic regression. RESULTS: Occupational exposures most strongly associated with COPD were diesel exhaust, irritant gases and vapors, mineral dust, and metal dust. The composite measures describing aggregate exposure to gases, vapors, solvents, or sensitizers (GVSS) and aggregate exposure to dust, GVSS, or diesel exhaust were also associated with COPD. In the small group of never-smokers, a similar pattern was evident. CONCLUSION: These population-based findings add to the literature linking occupational exposures to COPD.
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U2 - 10.1097/JOM.0b013e3181651556
DO - 10.1097/JOM.0b013e3181651556
M3 - Article
C2 - 18469625
AN - SCOPUS:43549085749
SN - 1076-2752
VL - 50
SP - 561
EP - 569
JO - Journal of occupational and environmental medicine
JF - Journal of occupational and environmental medicine
IS - 5
ER -