Cooperative tumorigenic effects of germline mutations in Rb and p53

Bart O. Williams, Lee Remington, Daniel Albert, Shizuo Mukai, Roderick T. Bronson, Tyler Jacks

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325 Scopus citations

Abstract

The tumour suppressor genes Rb and p53 are mutated in several types of human cancer, and many tumour types carry mutations in both genes. To study how these genes normally function, we and others have created mouse strains with Rb and p53 mutations. Here we describe the phenotypic effects of combined germline mutations in these two tumour suppressor genes. Mice mutant for both genes have reduced viability and exhibit novel pathology including pinealoblastomas, islet cell tumours, bronchial epithelial hyperplasia and retinal dysplasia. These data indicate that mutations in Rb and p53 can cooperate in the transformation of certain cell types in the mouse.

Original languageEnglish (US)
Pages (from-to)480-484
Number of pages5
JournalNature genetics
Volume7
Issue number4
DOIs
Publication statusPublished - Jan 1 1994
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics

Cite this

Williams, B. O., Remington, L., Albert, D., Mukai, S., Bronson, R. T., & Jacks, T. (1994). Cooperative tumorigenic effects of germline mutations in Rb and p53. Nature genetics, 7(4), 480-484. https://doi.org/10.1038/ng0894-480