Abstract
The convulsant potency of bicuculline, a GABA antagonist, was shown to be greater in Short-Sleep (SS) mice than in Long-Sleep (LS) mice. LS mice, selectively bred for lengthy ethanol-induced narcosis, had longer latencies to myoclonus and clonus following administration of bicuculline and picrotoxin than did ethanol-resistant SS mice. SS mice were also more susceptible to pentylenetetrazol-induced myoclonus, but not clonus. F1 hybrids showed bicuculline seizure sensitivity intermediate to the two parent lines. Ethanol weakly inhibited bicuculline-induced myoclonus in both LS and SS mice. Clonus was clearly antagonized by ethanol in both lines, but to a similar degree. These data provide evidence for a GABAergic role in geno-type-dependent sensitivity to ethanol.
Original language | English (US) |
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Pages (from-to) | 544-548 |
Number of pages | 5 |
Journal | Psychopharmacology |
Volume | 98 |
Issue number | 4 |
DOIs | |
State | Published - Aug 1989 |
Externally published | Yes |
Keywords
- Bicuculline
- Ethanol
- Genetics
- Picrotoxin
- Seizures
ASJC Scopus subject areas
- Pharmacology