Convulsant properties of GABA antagonists and anticonvulsant properties of ethanol in selectively bred Long- and Short-Sleep mice

Tamara J. Phillips, Duckhvun Kim, Bruce C. Dudek

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The convulsant potency of bicuculline, a GABA antagonist, was shown to be greater in Short-Sleep (SS) mice than in Long-Sleep (LS) mice. LS mice, selectively bred for lengthy ethanol-induced narcosis, had longer latencies to myoclonus and clonus following administration of bicuculline and picrotoxin than did ethanol-resistant SS mice. SS mice were also more susceptible to pentylenetetrazol-induced myoclonus, but not clonus. F1 hybrids showed bicuculline seizure sensitivity intermediate to the two parent lines. Ethanol weakly inhibited bicuculline-induced myoclonus in both LS and SS mice. Clonus was clearly antagonized by ethanol in both lines, but to a similar degree. These data provide evidence for a GABAergic role in geno-type-dependent sensitivity to ethanol.

Original languageEnglish (US)
Pages (from-to)544-548
Number of pages5
JournalPsychopharmacology
Volume98
Issue number4
DOIs
StatePublished - Aug 1 1989

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Keywords

  • Bicuculline
  • Ethanol
  • Genetics
  • Picrotoxin
  • Seizures

ASJC Scopus subject areas

  • Pharmacology

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