Conversion of methionine to homocysteine thiolactone in liver

Eliot Spindel, Kilmer S. McCully

    Research output: Contribution to journalArticlepeer-review

    26 Scopus citations


    Since hemocysteinemia is associated with arteriosclerosis, the conversion of methione to homocysteine thiolactone was studied in guinea pig liver in vivo. 60 min after intraperitoneal injection of [14C]methione, [14C]homocystein thiolactone was found to constitute 9.1% ± 0.2 of the lipid bound 14C and 20% ± 1.0 of the acid soluble 14C. This conversion is the first step of a new pathway by which the sulfur of methionine is transferred to phosphoadenosine phosphosulfate.

    Original languageEnglish (US)
    Pages (from-to)687-691
    Number of pages5
    JournalBBA - General Subjects
    Issue number3
    StatePublished - May 24 1974

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Molecular Biology

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