Since hemocysteinemia is associated with arteriosclerosis, the conversion of methione to homocysteine thiolactone was studied in guinea pig liver in vivo. 60 min after intraperitoneal injection of [14C]methione, [14C]homocystein thiolactone was found to constitute 9.1% ± 0.2 of the lipid bound 14C and 20% ± 1.0 of the acid soluble 14C. This conversion is the first step of a new pathway by which the sulfur of methionine is transferred to phosphoadenosine phosphosulfate.
ASJC Scopus subject areas
- Molecular Biology