TY - JOUR
T1 - Conversion of methionine to homocysteine thiolactone in liver
AU - Spindel, Eliot
AU - McCully, Kilmer S.
N1 - Funding Information:
We thank M. Arbuckle for excellent technical assistance and P. Clopath for helpful suggestions. The work was supported by the American Heart Association (73-655) and the National Institutes of Health (AM-15978 and CDA-HL-18747).
PY - 1974/5/24
Y1 - 1974/5/24
N2 - Since hemocysteinemia is associated with arteriosclerosis, the conversion of methione to homocysteine thiolactone was studied in guinea pig liver in vivo. 60 min after intraperitoneal injection of [14C]methione, [14C]homocystein thiolactone was found to constitute 9.1% ± 0.2 of the lipid bound 14C and 20% ± 1.0 of the acid soluble 14C. This conversion is the first step of a new pathway by which the sulfur of methionine is transferred to phosphoadenosine phosphosulfate.
AB - Since hemocysteinemia is associated with arteriosclerosis, the conversion of methione to homocysteine thiolactone was studied in guinea pig liver in vivo. 60 min after intraperitoneal injection of [14C]methione, [14C]homocystein thiolactone was found to constitute 9.1% ± 0.2 of the lipid bound 14C and 20% ± 1.0 of the acid soluble 14C. This conversion is the first step of a new pathway by which the sulfur of methionine is transferred to phosphoadenosine phosphosulfate.
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U2 - 10.1016/0304-4165(74)90290-6
DO - 10.1016/0304-4165(74)90290-6
M3 - Article
C2 - 4407042
AN - SCOPUS:0016186242
SN - 0304-4165
VL - 343
SP - 687
EP - 691
JO - BBA - General Subjects
JF - BBA - General Subjects
IS - 3
ER -