Conversion of methionine to homocysteine thiolactone in liver

Eliot Spindel, Kilmer S. McCully

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Since hemocysteinemia is associated with arteriosclerosis, the conversion of methione to homocysteine thiolactone was studied in guinea pig liver in vivo. 60 min after intraperitoneal injection of [14C]methione, [14C]homocystein thiolactone was found to constitute 9.1% ± 0.2 of the lipid bound 14C and 20% ± 1.0 of the acid soluble 14C. This conversion is the first step of a new pathway by which the sulfur of methionine is transferred to phosphoadenosine phosphosulfate.

Original languageEnglish (US)
Pages (from-to)687-691
Number of pages5
JournalBBA - General Subjects
Volume343
Issue number3
DOIs
StatePublished - May 24 1974
Externally publishedYes

Fingerprint

Phosphoadenosine Phosphosulfate
Arteriosclerosis
Intraperitoneal Injections
Sulfur
Methionine
Liver
Guinea Pigs
Lipids
Acids
homocysteine thiolactone

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Medicine(all)

Cite this

Conversion of methionine to homocysteine thiolactone in liver. / Spindel, Eliot; McCully, Kilmer S.

In: BBA - General Subjects, Vol. 343, No. 3, 24.05.1974, p. 687-691.

Research output: Contribution to journalArticle

Spindel, Eliot ; McCully, Kilmer S. / Conversion of methionine to homocysteine thiolactone in liver. In: BBA - General Subjects. 1974 ; Vol. 343, No. 3. pp. 687-691.
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