Convergent neurobiological predictors of emergent psychopathology during adolescence

Scott A. Jones, Angelica M. Morales, Jessye B. Lavine, Bonnie Nagel

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

The adolescent brain undergoes significant structural and functional development. Through the use of magnetic resonance imaging in adolescents, it has been demonstrated that the prefrontal cortex, pertinent for executive control, demonstrates protracted development compared to limbic structures, active during emotion and reward processing. This asynchronous development creates a sensitive window during adolescence, in which many psychopathological disorders (i.e., mental health and substance use) emerge. This review outlines longitudinal studies that use magnetic resonance imaging to identify neurobiological predictors of emergent psychopathology (depression, anxiety, and substance use), during adolescence. Studies identifying neurobiological markers that predict onset and escalation of these disorders, as well as those that predict successful treatment outcomes are explored. An emphasis is placed on frontolimbic brain structures, a convergent neurobiological target for both emergent mental health issues and emergent substance use. The literature reviewed herein suggests that reduced volume and cortical thickness in frontolimbic regions, as well as reduced functional activation (particularly during task involving reward or emotional stimuli) in these regions, may serve as a neurobiological predictors of emergent psychopathology in adolescence. This knowledge is crucial, as it may be used to develop neurobiologically targeted prevention and intervention strategies for youth who are at-risk for developing these psychopathologies.

Original languageEnglish (US)
Pages (from-to)1613-1622
Number of pages10
JournalBirth Defects Research
Volume109
Issue number20
DOIs
StatePublished - Dec 1 2017

Fingerprint

Magnetic resonance
Psychopathology
Brain
Health
Imaging techniques
Chemical activation
Reward
Mental Health
Processing
Magnetic Resonance Imaging
Executive Function
Prefrontal Cortex
Longitudinal Studies
Emotions
Anxiety
Depression

Keywords

  • adolescence
  • anxiety
  • depression
  • longitudinal
  • MRI
  • substance use

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Toxicology
  • Developmental Biology
  • Health, Toxicology and Mutagenesis

Cite this

Convergent neurobiological predictors of emergent psychopathology during adolescence. / Jones, Scott A.; Morales, Angelica M.; Lavine, Jessye B.; Nagel, Bonnie.

In: Birth Defects Research, Vol. 109, No. 20, 01.12.2017, p. 1613-1622.

Research output: Contribution to journalReview article

Jones, Scott A. ; Morales, Angelica M. ; Lavine, Jessye B. ; Nagel, Bonnie. / Convergent neurobiological predictors of emergent psychopathology during adolescence. In: Birth Defects Research. 2017 ; Vol. 109, No. 20. pp. 1613-1622.
@article{df0cd04abba84b6ab8ff984b080ad33e,
title = "Convergent neurobiological predictors of emergent psychopathology during adolescence",
abstract = "The adolescent brain undergoes significant structural and functional development. Through the use of magnetic resonance imaging in adolescents, it has been demonstrated that the prefrontal cortex, pertinent for executive control, demonstrates protracted development compared to limbic structures, active during emotion and reward processing. This asynchronous development creates a sensitive window during adolescence, in which many psychopathological disorders (i.e., mental health and substance use) emerge. This review outlines longitudinal studies that use magnetic resonance imaging to identify neurobiological predictors of emergent psychopathology (depression, anxiety, and substance use), during adolescence. Studies identifying neurobiological markers that predict onset and escalation of these disorders, as well as those that predict successful treatment outcomes are explored. An emphasis is placed on frontolimbic brain structures, a convergent neurobiological target for both emergent mental health issues and emergent substance use. The literature reviewed herein suggests that reduced volume and cortical thickness in frontolimbic regions, as well as reduced functional activation (particularly during task involving reward or emotional stimuli) in these regions, may serve as a neurobiological predictors of emergent psychopathology in adolescence. This knowledge is crucial, as it may be used to develop neurobiologically targeted prevention and intervention strategies for youth who are at-risk for developing these psychopathologies.",
keywords = "adolescence, anxiety, depression, longitudinal, MRI, substance use",
author = "Jones, {Scott A.} and Morales, {Angelica M.} and Lavine, {Jessye B.} and Bonnie Nagel",
year = "2017",
month = "12",
day = "1",
doi = "10.1002/bdr2.1176",
language = "English (US)",
volume = "109",
pages = "1613--1622",
journal = "Birth Defects Research",
issn = "2472-1727",
publisher = "John Wiley and Sons Ltd",
number = "20",

}

TY - JOUR

T1 - Convergent neurobiological predictors of emergent psychopathology during adolescence

AU - Jones, Scott A.

AU - Morales, Angelica M.

AU - Lavine, Jessye B.

AU - Nagel, Bonnie

PY - 2017/12/1

Y1 - 2017/12/1

N2 - The adolescent brain undergoes significant structural and functional development. Through the use of magnetic resonance imaging in adolescents, it has been demonstrated that the prefrontal cortex, pertinent for executive control, demonstrates protracted development compared to limbic structures, active during emotion and reward processing. This asynchronous development creates a sensitive window during adolescence, in which many psychopathological disorders (i.e., mental health and substance use) emerge. This review outlines longitudinal studies that use magnetic resonance imaging to identify neurobiological predictors of emergent psychopathology (depression, anxiety, and substance use), during adolescence. Studies identifying neurobiological markers that predict onset and escalation of these disorders, as well as those that predict successful treatment outcomes are explored. An emphasis is placed on frontolimbic brain structures, a convergent neurobiological target for both emergent mental health issues and emergent substance use. The literature reviewed herein suggests that reduced volume and cortical thickness in frontolimbic regions, as well as reduced functional activation (particularly during task involving reward or emotional stimuli) in these regions, may serve as a neurobiological predictors of emergent psychopathology in adolescence. This knowledge is crucial, as it may be used to develop neurobiologically targeted prevention and intervention strategies for youth who are at-risk for developing these psychopathologies.

AB - The adolescent brain undergoes significant structural and functional development. Through the use of magnetic resonance imaging in adolescents, it has been demonstrated that the prefrontal cortex, pertinent for executive control, demonstrates protracted development compared to limbic structures, active during emotion and reward processing. This asynchronous development creates a sensitive window during adolescence, in which many psychopathological disorders (i.e., mental health and substance use) emerge. This review outlines longitudinal studies that use magnetic resonance imaging to identify neurobiological predictors of emergent psychopathology (depression, anxiety, and substance use), during adolescence. Studies identifying neurobiological markers that predict onset and escalation of these disorders, as well as those that predict successful treatment outcomes are explored. An emphasis is placed on frontolimbic brain structures, a convergent neurobiological target for both emergent mental health issues and emergent substance use. The literature reviewed herein suggests that reduced volume and cortical thickness in frontolimbic regions, as well as reduced functional activation (particularly during task involving reward or emotional stimuli) in these regions, may serve as a neurobiological predictors of emergent psychopathology in adolescence. This knowledge is crucial, as it may be used to develop neurobiologically targeted prevention and intervention strategies for youth who are at-risk for developing these psychopathologies.

KW - adolescence

KW - anxiety

KW - depression

KW - longitudinal

KW - MRI

KW - substance use

UR - http://www.scopus.com/inward/record.url?scp=85038237279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85038237279&partnerID=8YFLogxK

U2 - 10.1002/bdr2.1176

DO - 10.1002/bdr2.1176

M3 - Review article

VL - 109

SP - 1613

EP - 1622

JO - Birth Defects Research

JF - Birth Defects Research

SN - 2472-1727

IS - 20

ER -