Controlled release levodopa/carbidopa 25/100 (Sinemet CR 25/100): Pharmacokinetics and clinical efficacy in untreated parkinsonian patients

John Hammerstad, William Woodward, John Nutt, S. T. Gancher, G. A. Block, G. Cyhan

Research output: Contribution to journalArticle

17 Scopus citations


The pharmacokinetics of the clinically determined optimal dose of controlled release levodopa/carbidopa 25/100 (Sinemet CR 25/100) after 12 weeks of therapy was studied in nine parkinsonian patients without prior exposure to levodopa. The pharmacokinetics of single oral doses of controlled release levodopa/carbidopa 25/100 and 50/200 were also compared. As predicted from the plasma half-life (1.7 ± 0.3 h) and confirmed by morning trough levels, levodopa did not accumulate when controlled released levodopa/carbidopa 25/100 was administered twice daily. The absorption and bioavailability of CR 25/100 are minimally greater than CR 50/200. Controlled released levodopa/carbidopa 25/100 levodopa plasma levels peak slightly faster than controlled release levodopa/carbidopa 50/200.

Original languageEnglish (US)
Pages (from-to)429-434
Number of pages6
JournalClinical Neuropharmacology
Issue number5
Publication statusPublished - 1994



  • Controlled release levodopa/carbidopa (Sinemet CR) 25/100
  • Levodopa
  • Parkinson's disease
  • Pharmacokinetics

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Clinical Neurology
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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