CONTROLLED CLINICAL TRIAL OF INTRAVENOUS ACYCLOVIR IN HEART-TRANSPLANT PATIENTS WITH MUCOCUTANEOUS HERPES SIMPLEX INFECTIONS

Sunwen Chou, JamesG Gallagher, ThomasC Merigan

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Viral Cultures of mucocutaneous herpes simplex lesions became negative in 5 heart-transplant patients given a 7-day course of intravenous acyclovir. Relief of pain and healing of lesions paralleled the virological response. Similar clinical and virological responses were not seen in the 5 placebo-treated patients in this double-blind placebo-controlled trial. No adverse reactions attributable to acyclovir were noted. Shedding of herpes simplex viruses recurred in 3 patients after acyclovir therapy.

Original languageEnglish (US)
Pages (from-to)1392-1394
Number of pages3
JournalThe Lancet
Volume317
Issue number8235
DOIs
StatePublished - Jun 27 1981
Externally publishedYes

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Herpes Simplex
Acyclovir
Controlled Clinical Trials
Transplants
Infection
Placebos
Simplexvirus
Pain
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

CONTROLLED CLINICAL TRIAL OF INTRAVENOUS ACYCLOVIR IN HEART-TRANSPLANT PATIENTS WITH MUCOCUTANEOUS HERPES SIMPLEX INFECTIONS. / Chou, Sunwen; Gallagher, JamesG; Merigan, ThomasC.

In: The Lancet, Vol. 317, No. 8235, 27.06.1981, p. 1392-1394.

Research output: Contribution to journalArticle

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