CONTROLLED CLINICAL TRIAL OF INTRAVENOUS ACYCLOVIR IN HEART-TRANSPLANT PATIENTS WITH MUCOCUTANEOUS HERPES SIMPLEX INFECTIONS

Sunwen Chou; James G. Gallagher; Thomas C. Merigan

doi:10.1016/S0140-6736(81)92570-8

CONTROLLED CLINICAL TRIAL OF INTRAVENOUS ACYCLOVIR IN HEART-TRANSPLANT PATIENTS WITH MUCOCUTANEOUS HERPES SIMPLEX INFECTIONS

Sunwen Chou, James G. Gallagher, Thomas C. Merigan

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Viral Cultures of mucocutaneous herpes simplex lesions became negative in 5 heart-transplant patients given a 7-day course of intravenous acyclovir. Relief of pain and healing of lesions paralleled the virological response. Similar clinical and virological responses were not seen in the 5 placebo-treated patients in this double-blind placebo-controlled trial. No adverse reactions attributable to acyclovir were noted. Shedding of herpes simplex viruses recurred in 3 patients after acyclovir therapy.

Original language	English (US)
Pages (from-to)	1392-1394
Number of pages	3
Journal	The Lancet
Volume	317
Issue number	8235
DOIs	https://doi.org/10.1016/S0140-6736(81)92570-8
State	Published - Jun 27 1981
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1016/S0140-6736(81)92570-8

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title = "CONTROLLED CLINICAL TRIAL OF INTRAVENOUS ACYCLOVIR IN HEART-TRANSPLANT PATIENTS WITH MUCOCUTANEOUS HERPES SIMPLEX INFECTIONS",

abstract = "Viral Cultures of mucocutaneous herpes simplex lesions became negative in 5 heart-transplant patients given a 7-day course of intravenous acyclovir. Relief of pain and healing of lesions paralleled the virological response. Similar clinical and virological responses were not seen in the 5 placebo-treated patients in this double-blind placebo-controlled trial. No adverse reactions attributable to acyclovir were noted. Shedding of herpes simplex viruses recurred in 3 patients after acyclovir therapy.",

author = "Sunwen Chou and Gallagher, {James G.} and Merigan, {Thomas C.}",

note = "Funding Information: in part by grants AM 13083 and AM 18883 from the National Institutes of Health, and by a grant from Burroughs Wellcome Company, U.S.A.",

year = "1981",

month = jun,

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doi = "10.1016/S0140-6736(81)92570-8",

language = "English (US)",

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AU - Chou, Sunwen

AU - Gallagher, James G.

AU - Merigan, Thomas C.

N1 - Funding Information: in part by grants AM 13083 and AM 18883 from the National Institutes of Health, and by a grant from Burroughs Wellcome Company, U.S.A.

PY - 1981/6/27

Y1 - 1981/6/27

N2 - Viral Cultures of mucocutaneous herpes simplex lesions became negative in 5 heart-transplant patients given a 7-day course of intravenous acyclovir. Relief of pain and healing of lesions paralleled the virological response. Similar clinical and virological responses were not seen in the 5 placebo-treated patients in this double-blind placebo-controlled trial. No adverse reactions attributable to acyclovir were noted. Shedding of herpes simplex viruses recurred in 3 patients after acyclovir therapy.

AB - Viral Cultures of mucocutaneous herpes simplex lesions became negative in 5 heart-transplant patients given a 7-day course of intravenous acyclovir. Relief of pain and healing of lesions paralleled the virological response. Similar clinical and virological responses were not seen in the 5 placebo-treated patients in this double-blind placebo-controlled trial. No adverse reactions attributable to acyclovir were noted. Shedding of herpes simplex viruses recurred in 3 patients after acyclovir therapy.

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CONTROLLED CLINICAL TRIAL OF INTRAVENOUS ACYCLOVIR IN HEART-TRANSPLANT PATIENTS WITH MUCOCUTANEOUS HERPES SIMPLEX INFECTIONS

Abstract

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