Control of systemic iron homeostasis by the hemojuvelin-hepcidin axis

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Systemic iron homeostasis is maintained by the coordinate regulation of iron absorption in the duodenum, iron recycling of senescent erythrocytes in macrophages, and mobilization of storage iron in the liver. These processes are controlled by hepcidin, a key iron regulatory hormone. Hepcidin is a 25-amino acid peptide secreted predominantly from hepatocytes. It downregulates ferroportin, the only known iron exporter, and therefore inhibits iron efflux from duodenal enterocytes, macrophages, and hepatocytes into the circulation. Hepcidin expression is regulated positively by body iron load. Although the underlying mechanism of iron-regulated hepcidin expression has not been fully elucidated, several proteins have been identified that participate in this process. Among them, hemojuvelin (HJV) plays a particularly important role. HJV undergoes complicated post-translational processing in an iron-dependent manner, and it interacts with multiple proteins that are essential for iron homeostasis. In this review, I focus on the recent findings that elucidate the role of HJV and its interacting partners in the modulation of hepatic hepcidin expression.

Original languageEnglish (US)
Pages (from-to)38-45
Number of pages8
JournalAdvances in Nutrition
Volume1
Issue number1
DOIs
StatePublished - Nov 2010

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Hepcidins
homeostasis
Homeostasis
Iron
iron
hepatocytes
macrophages
Hepatocytes
hepcidin
Macrophages
liver
iron absorption
enterocytes
Enterocytes
Liver
duodenum
recycling
Duodenum
erythrocytes
proteins

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Control of systemic iron homeostasis by the hemojuvelin-hepcidin axis. / Zhang, An-Sheng.

In: Advances in Nutrition, Vol. 1, No. 1, 11.2010, p. 38-45.

Research output: Contribution to journalArticle

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