Control of Presynaptic Function by a Persistent Na+ Current

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Little is known about ion channels that regulate the graded, subthreshold properties of nerve terminals. Using the calyx of Held, we demonstrate here a large presynaptic persistent Na+ current with unusually hyperpolarized activation voltage. This feature allowed the current to determine both the resting potential and resting conductance of the nerve terminal. Calyces express presynaptic glycine receptors whose activation depolarizes the synapse. We found that activation of the persistent Na+ current was an essential component in the response to glycine. This Na+ current originated at or very close to the terminal and was sustained even after trains of large spike-like depolarizations. Because Na+ channels also underlie the presynaptic action potential, we conclude that their action both triggers and modulates exocytosis through control of presynaptic membrane voltage.

Original languageEnglish (US)
Pages (from-to)975-979
Number of pages5
JournalNeuron
Volume60
Issue number6
DOIs
StatePublished - Dec 26 2008

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Glycine Receptors
Presynaptic Receptors
Exocytosis
Ion Channels
Membrane Potentials
Synapses
Glycine
Action Potentials
Membranes

Keywords

  • CELLBIO
  • MOLNEURO
  • SIGNALING

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Control of Presynaptic Function by a Persistent Na+ Current. / Huang, Hai; Trussell, Laurence.

In: Neuron, Vol. 60, No. 6, 26.12.2008, p. 975-979.

Research output: Contribution to journalArticle

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