Control of memory CD8+ T cell longevity and effector functions by IL-15

Jeffrey C. Nolz; Martin J. Richer

doi:10.1016/j.molimm.2019.11.011

Control of memory CD8⁺ T cell longevity and effector functions by IL-15

Jeffrey C. Nolz, Martin J. Richer

Molecular Microbiology and Immunology

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

IL-15 is a member of the common gamma chain family of cytokines and plays important roles in regulating several aspects of innate and adaptive immunity. Besides its established role in controlling homeostatic proliferation and survival of memory CD8⁺ T cells and natural killer cells, recent findings demonstrate that inflammatory IL-15 can also stimulate a variety of effector functions, such as enhanced cytotoxicity, entry into the cell cycle, and trafficking into non-lymphoid tissues. Here, we discuss how IL-15 is critical in regulating many functions of memory CD8⁺ T cells and how these processes act collectively to ensure optimal protective cellular immunity against re-infections.

Original language	English (US)
Pages (from-to)	180-188
Number of pages	9
Journal	Molecular Immunology
Volume	117
DOIs	https://doi.org/10.1016/j.molimm.2019.11.011
State	Published - Jan 2020

ASJC Scopus subject areas

Immunology
Molecular Biology

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10.1016/j.molimm.2019.11.011

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abstract = "IL-15 is a member of the common gamma chain family of cytokines and plays important roles in regulating several aspects of innate and adaptive immunity. Besides its established role in controlling homeostatic proliferation and survival of memory CD8+ T cells and natural killer cells, recent findings demonstrate that inflammatory IL-15 can also stimulate a variety of effector functions, such as enhanced cytotoxicity, entry into the cell cycle, and trafficking into non-lymphoid tissues. Here, we discuss how IL-15 is critical in regulating many functions of memory CD8+ T cells and how these processes act collectively to ensure optimal protective cellular immunity against re-infections.",

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AB - IL-15 is a member of the common gamma chain family of cytokines and plays important roles in regulating several aspects of innate and adaptive immunity. Besides its established role in controlling homeostatic proliferation and survival of memory CD8+ T cells and natural killer cells, recent findings demonstrate that inflammatory IL-15 can also stimulate a variety of effector functions, such as enhanced cytotoxicity, entry into the cell cycle, and trafficking into non-lymphoid tissues. Here, we discuss how IL-15 is critical in regulating many functions of memory CD8+ T cells and how these processes act collectively to ensure optimal protective cellular immunity against re-infections.

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Control of memory CD8⁺ T cell longevity and effector functions by IL-15

Abstract

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