@article{d24d3757094d46bcb5903b873a1a7be4,
title = "Control of memory CD8+ T cell longevity and effector functions by IL-15",
abstract = "IL-15 is a member of the common gamma chain family of cytokines and plays important roles in regulating several aspects of innate and adaptive immunity. Besides its established role in controlling homeostatic proliferation and survival of memory CD8+ T cells and natural killer cells, recent findings demonstrate that inflammatory IL-15 can also stimulate a variety of effector functions, such as enhanced cytotoxicity, entry into the cell cycle, and trafficking into non-lymphoid tissues. Here, we discuss how IL-15 is critical in regulating many functions of memory CD8+ T cells and how these processes act collectively to ensure optimal protective cellular immunity against re-infections.",
author = "Nolz, {Jeffrey C.} and Richer, {Martin J.}",
note = "Funding Information: The authors would like to thank the members of the Nolz and Richer labs for helpful discussions and Dr. Stephanie A. Condotta for generating figures and critical reading of the manuscript. Research in the Nolz lab is supported by the National Institutes of Health ( R01-AI132404 ). Research in the Richer Lab is supported by the Canadian Institutes of Health Research ( PJT-152903 , PJT-162212 ); the Natural Sciences and Engineering Research Council of Canada ( RGPIN-2016-04713 ); and the Canada Foundation for Innovation . MJ Richer is supported by salary awards from the Canadian Institutes of Health Research and the Fonds de Recherche du Qu{\'e}bec – Sant{\'e} . Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2020",
month = jan,
doi = "10.1016/j.molimm.2019.11.011",
language = "English (US)",
volume = "117",
pages = "180--188",
journal = "Immunochemistry",
issn = "0161-5890",
publisher = "Elsevier Limited",
}