Control of lymphocyte homing

Research output: Contribution to journalArticle

166 Scopus citations

Abstract

The expression of immunity, both protective and pathologic, is critically dependent on the appropriate distribution of 'lymphoid resources' among the tissues of the body. The 'homing' mechanisms mediating this distribution have proven to have an astounding plasticity - directing, under strict microenvironmental control, the selective recruitment of specific lymphocyte subsets to the various secondary lymphoid tissues and extralymphoid immune effector sites. The past year has seen significant progress in our understanding in three areas: the molecular basis of lymphocyte interactions with endothelium, providing new insight into the complex multistep process of lymphocyte extravasation; the role of extravascular matrix and cells in retaining lymphocytes within tissues; and the mechanisms by which local microenvironments differentially regulate adhesion molecule expression and function so as to provide for site-selective lymphocyte homing.

Original languageEnglish (US)
Pages (from-to)394-406
Number of pages13
JournalCurrent opinion in immunology
Volume6
Issue number3
DOIs
StatePublished - Jun 1994

Keywords

  • CLA-cutaneous lymphocyte-associated antigen
  • EC-endothelial cell
  • HEV-high endothelial venule
  • HUVEC-human umbilical vein endothelial cell
  • ICAM-1, -2 -3-intercellular adhesion molecule -1, 2, -3
  • Ig-immunoglobulin
  • LFA-1-lymphocyte function antigen-1
  • LVAP-2-lymphocyte vascular adhesion protein-2
  • MAdCAM-1-mucosal vascular addressin cell molecule-1
  • MIP-macrophage inflammatory protein
  • MLA-mucosal lymphocyte antigen
  • PECAM-1-platelet endothelial cell adhesion molecule-1
  • PLN-peripheral lymph node
  • PNAd-peripheral lymp node addressin
  • VAP-1-vascular adhesion protein-1
  • VCAM-1-vascular cell adhesion molecule-1
  • maAb-monoclonal antibody

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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