Control of crystal size and lattice formation by starmaker in otolith biomineratization

Christian Söllner, Manfred Burghammer, Elisabeth Busch-Nentwich, Jürgen Berger, Heinz Schwarz, Christian Riekel, Teresa Nicolson

Research output: Contribution to journalArticle

201 Citations (Scopus)

Abstract

The stone-like otoliths from the ears of teleost fishes are involved in balance and hearing and consist of calcium carbonate crystallites embedded in a protein framework. We report that a previously unknown gene, starmaker, is required in zebrafish for otolith morphogenesis. Reduction of starmaker activity by injection of modified antisense oligonucleotides causes a change in the crystal lattice structure and thus a change in otolith morphology. The expression pattern of starmaker, along with the presence of the protein on the growing otolith, suggest that the expression levels of starmaker control the shape of the otoliths.

Original languageEnglish (US)
Pages (from-to)282-286
Number of pages5
JournalScience
Volume302
Issue number5643
DOIs
StatePublished - Oct 10 2003

Fingerprint

Otolithic Membrane
Calcium Carbonate
Antisense Oligonucleotides
Zebrafish
Morphogenesis
Hearing
Ear
Fishes
Proteins
Injections
Genes

ASJC Scopus subject areas

  • General

Cite this

Söllner, C., Burghammer, M., Busch-Nentwich, E., Berger, J., Schwarz, H., Riekel, C., & Nicolson, T. (2003). Control of crystal size and lattice formation by starmaker in otolith biomineratization. Science, 302(5643), 282-286. https://doi.org/10.1126/science.1088443

Control of crystal size and lattice formation by starmaker in otolith biomineratization. / Söllner, Christian; Burghammer, Manfred; Busch-Nentwich, Elisabeth; Berger, Jürgen; Schwarz, Heinz; Riekel, Christian; Nicolson, Teresa.

In: Science, Vol. 302, No. 5643, 10.10.2003, p. 282-286.

Research output: Contribution to journalArticle

Söllner, C, Burghammer, M, Busch-Nentwich, E, Berger, J, Schwarz, H, Riekel, C & Nicolson, T 2003, 'Control of crystal size and lattice formation by starmaker in otolith biomineratization', Science, vol. 302, no. 5643, pp. 282-286. https://doi.org/10.1126/science.1088443
Söllner C, Burghammer M, Busch-Nentwich E, Berger J, Schwarz H, Riekel C et al. Control of crystal size and lattice formation by starmaker in otolith biomineratization. Science. 2003 Oct 10;302(5643):282-286. https://doi.org/10.1126/science.1088443
Söllner, Christian ; Burghammer, Manfred ; Busch-Nentwich, Elisabeth ; Berger, Jürgen ; Schwarz, Heinz ; Riekel, Christian ; Nicolson, Teresa. / Control of crystal size and lattice formation by starmaker in otolith biomineratization. In: Science. 2003 ; Vol. 302, No. 5643. pp. 282-286.
@article{30e142c8d462417a9827fff281da2c51,
title = "Control of crystal size and lattice formation by starmaker in otolith biomineratization",
abstract = "The stone-like otoliths from the ears of teleost fishes are involved in balance and hearing and consist of calcium carbonate crystallites embedded in a protein framework. We report that a previously unknown gene, starmaker, is required in zebrafish for otolith morphogenesis. Reduction of starmaker activity by injection of modified antisense oligonucleotides causes a change in the crystal lattice structure and thus a change in otolith morphology. The expression pattern of starmaker, along with the presence of the protein on the growing otolith, suggest that the expression levels of starmaker control the shape of the otoliths.",
author = "Christian S{\"o}llner and Manfred Burghammer and Elisabeth Busch-Nentwich and J{\"u}rgen Berger and Heinz Schwarz and Christian Riekel and Teresa Nicolson",
year = "2003",
month = "10",
day = "10",
doi = "10.1126/science.1088443",
language = "English (US)",
volume = "302",
pages = "282--286",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5643",

}

TY - JOUR

T1 - Control of crystal size and lattice formation by starmaker in otolith biomineratization

AU - Söllner, Christian

AU - Burghammer, Manfred

AU - Busch-Nentwich, Elisabeth

AU - Berger, Jürgen

AU - Schwarz, Heinz

AU - Riekel, Christian

AU - Nicolson, Teresa

PY - 2003/10/10

Y1 - 2003/10/10

N2 - The stone-like otoliths from the ears of teleost fishes are involved in balance and hearing and consist of calcium carbonate crystallites embedded in a protein framework. We report that a previously unknown gene, starmaker, is required in zebrafish for otolith morphogenesis. Reduction of starmaker activity by injection of modified antisense oligonucleotides causes a change in the crystal lattice structure and thus a change in otolith morphology. The expression pattern of starmaker, along with the presence of the protein on the growing otolith, suggest that the expression levels of starmaker control the shape of the otoliths.

AB - The stone-like otoliths from the ears of teleost fishes are involved in balance and hearing and consist of calcium carbonate crystallites embedded in a protein framework. We report that a previously unknown gene, starmaker, is required in zebrafish for otolith morphogenesis. Reduction of starmaker activity by injection of modified antisense oligonucleotides causes a change in the crystal lattice structure and thus a change in otolith morphology. The expression pattern of starmaker, along with the presence of the protein on the growing otolith, suggest that the expression levels of starmaker control the shape of the otoliths.

UR - http://www.scopus.com/inward/record.url?scp=0141924547&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141924547&partnerID=8YFLogxK

U2 - 10.1126/science.1088443

DO - 10.1126/science.1088443

M3 - Article

C2 - 14551434

AN - SCOPUS:0141924547

VL - 302

SP - 282

EP - 286

JO - Science

JF - Science

SN - 0036-8075

IS - 5643

ER -