TY - JOUR
T1 - Control of crystal size and lattice formation by starmaker in otolith biomineratization
AU - Söllner, Christian
AU - Burghammer, Manfred
AU - Busch-Nentwich, Elisabeth
AU - Berger, Jürgen
AU - Schwarz, Heinz
AU - Riekel, Christian
AU - Nicolson, Teresa
PY - 2003/10/10
Y1 - 2003/10/10
N2 - The stone-like otoliths from the ears of teleost fishes are involved in balance and hearing and consist of calcium carbonate crystallites embedded in a protein framework. We report that a previously unknown gene, starmaker, is required in zebrafish for otolith morphogenesis. Reduction of starmaker activity by injection of modified antisense oligonucleotides causes a change in the crystal lattice structure and thus a change in otolith morphology. The expression pattern of starmaker, along with the presence of the protein on the growing otolith, suggest that the expression levels of starmaker control the shape of the otoliths.
AB - The stone-like otoliths from the ears of teleost fishes are involved in balance and hearing and consist of calcium carbonate crystallites embedded in a protein framework. We report that a previously unknown gene, starmaker, is required in zebrafish for otolith morphogenesis. Reduction of starmaker activity by injection of modified antisense oligonucleotides causes a change in the crystal lattice structure and thus a change in otolith morphology. The expression pattern of starmaker, along with the presence of the protein on the growing otolith, suggest that the expression levels of starmaker control the shape of the otoliths.
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U2 - 10.1126/science.1088443
DO - 10.1126/science.1088443
M3 - Article
C2 - 14551434
AN - SCOPUS:0141924547
SN - 0036-8075
VL - 302
SP - 282
EP - 286
JO - Science
JF - Science
IS - 5643
ER -