Control of chronic excessive alcohol drinking by genetic manipulation of the Edinger-Westphal nucleus urocortin-1 neuropeptide system

W. J. Giardino, E. D. Rodriguez, M. L. Smith, Matthew Ford, D. Galili, Suzanne Mitchell, A. Chen, Andrey Ryabinin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Midbrain neurons of the centrally projecting Edinger-Westphal nucleus (EWcp) are activated by alcohol, and enriched with stress-responsive neuropeptide modulators (including the paralog of corticotropin-releasing factor, urocortin-1). Evidence suggests that EWcp neurons promote behavioral processes for alcohol-seeking and consumption, but a definitive role for these cells remains elusive. Here we combined targeted viral manipulations and gene array profiling of EWcp neurons with mass behavioral phenotyping in C57BL/6 J mice to directly define the links between EWcp-specific urocortin-1 expression and voluntary binge alcohol intake, demonstrating a specific importance for EWcp urocortin-1 activity in escalation of alcohol intake.

Original languageEnglish (US)
Article numbere1021
JournalTranslational Psychiatry
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2017

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Urocortins
Neuropeptides
Alcohol Drinking
Alcohols
Neurons
Viral Genes
Corticotropin-Releasing Hormone
Mesencephalon
Edinger-Westphal Nucleus

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Biological Psychiatry

Cite this

Control of chronic excessive alcohol drinking by genetic manipulation of the Edinger-Westphal nucleus urocortin-1 neuropeptide system. / Giardino, W. J.; Rodriguez, E. D.; Smith, M. L.; Ford, Matthew; Galili, D.; Mitchell, Suzanne; Chen, A.; Ryabinin, Andrey.

In: Translational Psychiatry, Vol. 7, No. 1, e1021, 01.01.2017.

Research output: Contribution to journalArticle

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