@article{941580f1891549619d9fbcdd8820253d,
title = "Control of chronic excessive alcohol drinking by genetic manipulation of the Edinger-Westphal nucleus urocortin-1 neuropeptide system",
abstract = "Midbrain neurons of the centrally projecting Edinger-Westphal nucleus (EWcp) are activated by alcohol, and enriched with stress-responsive neuropeptide modulators (including the paralog of corticotropin-releasing factor, urocortin-1). Evidence suggests that EWcp neurons promote behavioral processes for alcohol-seeking and consumption, but a definitive role for these cells remains elusive. Here we combined targeted viral manipulations and gene array profiling of EWcp neurons with mass behavioral phenotyping in C57BL/6 J mice to directly define the links between EWcp-specific urocortin-1 expression and voluntary binge alcohol intake, demonstrating a specific importance for EWcp urocortin-1 activity in escalation of alcohol intake.",
author = "Giardino, {W. J.} and Rodriguez, {E. D.} and Smith, {M. L.} and Ford, {M. M.} and D. Galili and Mitchell, {S. H.} and A. Chen and Ryabinin, {A. E.}",
note = "Funding Information: The National Institute on Alcohol Abuse and Alcoholism provided grant support to the Portland Alcohol Research Center (P60 AA010760), A.E. Ryabinin (R01 AA013738, U01 AA016647), and W.J. Giardino (F31 AA021023). Dawn M. Cote, Ju Li, Dr Caroline M. Hostetler, Dr Allison M.J. Anacker, Dr Juan L. Gomez, Natalie L. Davis, and Ashley D. Ermann provided technical assistance. Benjamin M. Weintraub wrote the Ruby script for extraction of lickometer data and subsequent alcohol bout analyses. Dr Deborah A. Finn and Chris Snelling provided logistical assistance with study facilities. The laboratory of Dr. Wylie Vale donated knockout mice. Publisher Copyright: {\textcopyright} The Author(s) 2017.",
year = "2017",
doi = "10.1038/tp.2016.293",
language = "English (US)",
volume = "7",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "Nature Publishing Group",
number = "1",
}