Heptahelical G protein-coupled receptors (GPCRs) are located in the cell's plasma membrane and are responsible for transmitting chemical signals across the lipid bilayer. GPCRs comprise a large family of related receptors that have evolved to bind a wide range of extracellular ligands, from biogenic amines and neuromodulatory peptides to peptide hormones and proteins, and to lipids and fatty acids, to name but a few. Recent advances in the study of structural biology of GPCRs, including reports of high-resolution crystal structures of nearly ten different receptors have transformed the field. Beginning in the mid-1980's and continuing until his retirement, H Gobind Khorana and his co-workers at MIT worked on the prototypical GPCR rhodopsin and provided an early framework of experimental technologies and discoverieswhich propelled the field forward and continue to have a huge impact on literally hundreds of laboratories worldwide.
- Signal transduction
ASJC Scopus subject areas