Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of Schizophrenia

John H. Krystal, Bita Moghaddam

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Citations (Scopus)

Abstract

Glutamatergic and GABAergic neuropathology in schizophrenia Psychopharmacology and physiology of glutamate and GABA systems Implications Acknowledgements References

Original languageEnglish (US)
Title of host publicationSchizophrenia: Third Edition
PublisherWiley-Blackwell
Pages433-461
Number of pages29
ISBN (Print)9781405176972
DOIs
StatePublished - Mar 8 2011
Externally publishedYes

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Psychopharmacology
Neurobiology
gamma-Aminobutyric Acid
Glutamic Acid
Schizophrenia
Neuropathology

Keywords

  • Contributions of glutamate and GABA systems - to neurobiology and treatment of schizophrenia
  • Drugs, enhancing glutamatergic activation - cognitive deficits and reductions in cortical metabolism
  • GABA receptors alterations in GABA receptor populations - heritable vulnerability to schizophrenia
  • Glutamate receptor subunit and synaptic proteins - in schizophrenia using postmortem brain samples
  • Glutamate-related synaptic proteins - marked by a high degree of heterogeneity
  • Glutamatergic and GABAergic neuropathology - in schizophrenia
  • Glutamatergic neuropathology, in schizophrenia - and reduced glutamate neural connectivity
  • Metabotropic glutamate receptors (mGluR)
  • NMDA receptors, stimulated - molecules of glutamate and glycine bind to a receptor, "activated" by membrane depolarization
  • Two approaches, reducing glutamate release - blocking voltage-gated cation channels and stimulating Group II mGlu receptors

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of Schizophrenia. / Krystal, John H.; Moghaddam, Bita.

Schizophrenia: Third Edition. Wiley-Blackwell, 2011. p. 433-461.

Research output: Chapter in Book/Report/Conference proceedingChapter

Krystal, John H. ; Moghaddam, Bita. / Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of Schizophrenia. Schizophrenia: Third Edition. Wiley-Blackwell, 2011. pp. 433-461
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