Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of Schizophrenia

John H. Krystal, Bita Moghaddam

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations

Abstract

Glutamatergic and GABAergic neuropathology in schizophrenia Psychopharmacology and physiology of glutamate and GABA systems Implications Acknowledgements References

Original languageEnglish (US)
Title of host publicationSchizophrenia
Subtitle of host publicationThird Edition
PublisherWiley-Blackwell
Pages433-461
Number of pages29
ISBN (Print)9781405176972
DOIs
StatePublished - Mar 8 2011

Keywords

  • Contributions of glutamate and GABA systems - to neurobiology and treatment of schizophrenia
  • Drugs, enhancing glutamatergic activation - cognitive deficits and reductions in cortical metabolism
  • GABA receptors alterations in GABA receptor populations - heritable vulnerability to schizophrenia
  • Glutamate receptor subunit and synaptic proteins - in schizophrenia using postmortem brain samples
  • Glutamate-related synaptic proteins - marked by a high degree of heterogeneity
  • Glutamatergic and GABAergic neuropathology - in schizophrenia
  • Glutamatergic neuropathology, in schizophrenia - and reduced glutamate neural connectivity
  • Metabotropic glutamate receptors (mGluR)
  • NMDA receptors, stimulated - molecules of glutamate and glycine bind to a receptor, "activated" by membrane depolarization
  • Two approaches, reducing glutamate release - blocking voltage-gated cation channels and stimulating Group II mGlu receptors

ASJC Scopus subject areas

  • Medicine(all)

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