Abstract
Glutamatergic and GABAergic neuropathology in schizophrenia Psychopharmacology and physiology of glutamate and GABA systems Implications Acknowledgements References
| Original language | English (US) |
|---|---|
| Title of host publication | Schizophrenia |
| Subtitle of host publication | Third Edition |
| Publisher | Wiley-Blackwell |
| Pages | 433-461 |
| Number of pages | 29 |
| ISBN (Print) | 9781405176972 |
| DOIs | |
| State | Published - Mar 8 2011 |
| Externally published | Yes |
Keywords
- Contributions of glutamate and GABA systems - to neurobiology and treatment of schizophrenia
- Drugs, enhancing glutamatergic activation - cognitive deficits and reductions in cortical metabolism
- GABA receptors alterations in GABA receptor populations - heritable vulnerability to schizophrenia
- Glutamate receptor subunit and synaptic proteins - in schizophrenia using postmortem brain samples
- Glutamate-related synaptic proteins - marked by a high degree of heterogeneity
- Glutamatergic and GABAergic neuropathology - in schizophrenia
- Glutamatergic neuropathology, in schizophrenia - and reduced glutamate neural connectivity
- Metabotropic glutamate receptors (mGluR)
- NMDA receptors, stimulated - molecules of glutamate and glycine bind to a receptor, "activated" by membrane depolarization
- Two approaches, reducing glutamate release - blocking voltage-gated cation channels and stimulating Group II mGlu receptors
ASJC Scopus subject areas
- General Medicine