The conversion of dehydroepiandrosterone sulfate (DS) to testosterone (T) and the DS production rate were quantified preand postoperatively in a virilized 32-yr-old female with an arrhenoblastoma. Additionally, at the time of operation, the tumor was isolated and perfused with DS-4-14C and T-7α-3H and the venous effluent collected. Preoperatively, the maximum quantity of plasma T derived from circulating DS was 640 µg/day. Postoperatively, this figure was found to be 310 µg/day. The preoperative DS production rate was 80 mg/day, with the postoperative production rate falling to 15.5 mg/day. Labeled DS perfused through the tumor was not converted to T, testosterone sulfate or androstenedione. A small conversion of DS to dehydroepiandrosterone was noted. It is concluded that the conversion of circulating DS to T by the tumor itself was not an important factor in the genesis of this patient’s virilism. Likewise, the peripheral conversion of circulating DS to T did not appear to be significant in terms of the clinical status of the patient. The tumor was the major source of circulating DS prior to operation.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Clinical Biochemistry
- Biochemistry, medical